Evidence map›Paper›PMID 36871154›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by Translated Peptide ATMLP Under the Control of m

Hailong Pei, Yingchu Dai, Yongduo Yu, Jiaxin Tang, Zhifei Cao, Yongsheng Zhang, Bingyan Li, Jing Nie, Tom K Hei, Guangming Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Hailong PeiState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Jiangsu, Suzhou, 215123, P. R. China.ORCID 0000-0002-9458-6027
Yingchu DaiState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Jiangsu, Suzhou, 215123, P. R. China.
Yongduo YuState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Jiangsu, Suzhou, 215123, P. R. China.
Jiaxin TangState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Jiangsu, Suzhou, 215123, P. R. China.
Zhifei CaoDepartment of Pathology, The Second Affiliated Hospital of Soochow University, Jiangsu, Suzhou, 215004, P. R. China.
Yongsheng ZhangDepartment of Pathology, The Second Affiliated Hospital of Soochow University, Jiangsu, Suzhou, 215004, P. R. China.
Bingyan LiState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Jiangsu, Suzhou, 215123, P. R. China.
Jing NieState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Jiangsu, Suzhou, 215123, P. R. China.
Tom K HeiCenter for Radiological Research, College of Physician and Surgeons, Columbia University, New York, NY, 10032, USA.
Guangming ZhouState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Jiangsu, Suzhou, 215123, P. R. China.
Soochow University · CNColumbia University · US

Funding

National Natural Science Foundation of China 82073480National Natural Science Foundation of China 82192883National Natural Science Foundation of China 82273578
6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) in eukaryotic transcripts have long been believed to regulate various aspects of cellular processes, including carcinogenesis. Herein, it is found that lncRNA AFAP1-AS1 encodes a conserved 90-amino acid peptide located on mitochondria, named lncRNA AFAP1-AS1 translated mitochondrial-localized peptide (ATMLP), and it is not the lncRNA but the peptide that promotes the malignancy of nonsmall cell lung cancer (NSCLC). As the tumor progresses, the serum level of ATMLP increases. NSCLC patients with high levels of ATMLP display poorer prognosis. Translation of ATMLP is controlled by m

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsRNA, Long NoncodingCarcinogenesisCell Line, TumorHumansIntercellular Signaling Peptides and ProteinsMethylationMitochondriaAFAP1-AS1 long noncoding RNA, humanIntercellular Signaling Peptides and ProteinsNIPSNAP1 protein, humanRNA, Long Noncodingautolysosomesionizing radiationmitophagyN6-methyladenosinetumorigenesis

Identifiers

PMID36871154
PMCPMC10161021
OpenAlexW4323255472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.