Evidence map›Paper›PMID 36871132›Full record

ArticleJPEN. Journal of parenteral and enteral nutrition2023

Characteristics and outcomes of patients with gastroparesis using enteral and/or exclusive parenteral nutrition.

Henry P Parkman, Amanda L Blackford, Helen Burton Murray, Katherine P Yates, Madhusudan Grover, Zubair Malik, Ron Schey, Robert S Bulat, Kenneth L Koch, Irene Sarosiek and 11 more

Open access · greenAbstract read
In one paragraph

Article in JPEN. Journal of parenteral and enteral nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Characterization of Patients With Symptoms of Gastroparesis Having Frequent Emergency Department Visits and Hospitalizations.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
    Article
  2. Article
  3. Scoping review: the social and emotional impacts of gastroparesis.Translational gastroenterology and hepatology · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 1 country.

Henry P ParkmanGastroenterology Section, Department of Medicine, Temple University, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4904-4891
Amanda L BlackfordDepartments of Medicine and Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Helen Burton MurrayDepartment of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Katherine P YatesDepartments of Medicine and Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Madhusudan GroverDepartment of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.
Zubair MalikGastroenterology Section, Department of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Ron ScheyGastroenterology Section, Department of Medicine, Temple University, Philadelphia, Pennsylvania, USA.
Robert S BulatDepartments of Medicine and Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Kenneth L KochDepartment of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
Irene SarosiekDepartment of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA.
Braden KuoDepartment of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Robert J ShulmanDepartment of Medicine, Baylor School of Medicine, Houston, Texas, USA.
Bruno P ChumpitaziDepartment of Medicine, Baylor School of Medicine, Houston, Texas, USA.
Gianrico FarrugiaDepartment of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.
Laura MirielDepartments of Medicine and Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
James TonasciaDepartments of Medicine and Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Frank HamiltonNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Pankaj J PasrichaDepartments of Medicine and Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Richard W McCallumDepartment of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA.
Thomas L AbellDepartment of Medicine, University of Louisville, Louisville, Kentucky, USA.ORCID 0000-0002-3175-5161
NIDDK Gastroparesis Clinical Research Consortium
Johns Hopkins University · USTemple University · USBaylor School · USHarvard University · USMayo Clinic · USTexas Tech University · USNational Institutes of Health · USUniversity of Louisville · USWake Forest University · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Gastroparesis Consortium Continuation-Data Coordinating CenterU01DK074008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TONASCIA, JAMES A · 2006 to 2015
$17.4M
PGpR2 Year 4 Supplement for the Scientific Data Research Center (SDRC) of the GpCRC 4U24DK074008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI David M Shade · 2017 to 2026
$11.7M
Subtypes of GastroparesisU01DK073974 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Baharak Moshiree · 2006 to 2026
$7.4M
Temple University Gastroparesis Clinical CenterU01DK073975 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI HENRY PAUL PARKMAN · 2006 to 2026
$7.4M
U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis ConsortiumU01DK074007 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Thomas Lyman Abell · 2006 to 2026
$7.0M
Molecular Approaches to Pathogenesis/Therapy in GastropaU01DK073983 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PANKAJ J PASRICHA · 2006 to 2026
$6.8M
The GpCRC Pediatric Gastroparesis Registry 2 (PGpR2): Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants with Symptoms of GastU01DK074035 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Irene Sarosiek · 2008 to 2026
$6.7M
Institute for Clinical and Translational ResearchUL1TR000424 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2012 to 2012
$6.0M
New England Gastropareis Consortium: Neurobiology of GastroparesisU01DK112193 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Helen Burton Murray, Braden Kuo · 2016 to 2026
$4.8M
A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional DyspepsiaK23DK131334 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BURTON MURRAY, HELEN · 2021 to 2025
$1.1M
NCATS NIH HHS UL1 TR000424NIDDK NIH HHS K23 DK131334NIDDK NIH HHS U01 DK073974NIDDK NIH HHS U01 DK073975NIDDK NIH HHS U01 DK073983NIDDK NIH HHS U01 DK074007NIDDK NIH HHS U01 DK074008NIDDK NIH HHS U01 DK074035NIDDK NIH HHS U01 DK112193NIDDK NIH HHS U24 DK074008
6 · The paper itself

Abstract

backgroundPatients with gastroparesis (Gp) may need enteral nutrition (EN) or exclusive parenteral nutrition (PN). Among patients with Gp, we aimed to (1) identify the frequency of EN and exclusive PN use and (2) explore characteristics of patients using EN and/or exclusive PN compared with those using oral nutrition (ON), including changes over 48 weeks.

methodsPatients with Gp underwent history and physical examination, gastric emptying scintigraphy, water load satiety testing (WLST), and questionnaires assessing gastrointestinal symptoms and quality of life (QOL). Patients were observed 48 weeks.

resultsOf 971 patients with Gp (idiopathic, 579; diabetic, 336; post-Nissen fundoplication, 51), 939 (96.7%) were using ON only, 14 (1.4%) using exclusive PN, and 18 (1.9%) using EN. Compared with patients receiving ON, patients receiving exclusive PN and/or EN were younger, had lower body mass index, and had greater symptom severity. Patients receiving exclusive PN and/or EN had lower physical QOL but not mental QOL or Gp-related QOL scores. Patients receiving exclusive PN and/or EN ingested less water during WLST but did not have worse gastric emptying. Of those who had been receiving exclusive PN and/or EN, 50% and 25%, respectively, resumed ON at 48-week follow-up.

conclusionsThis study describes patients with Gp requiring exclusive PN and/or EN for nutrition support, who represent a small (3.3%) but important subset of patients with Gp. Unique clinical and physiological parameters are associated with this subset and provide insight into the use of nutrition support in Gp.

Indexed as

GastroparesisEnteral NutritionHumansNutritional SupportParenteral NutritionQuality of Lifeenteral nutritiongastric emptyinggastroparesisidiopathic gastroparesisobesityparenteral nutrition

Identifiers

PMID36871132
PMCPMC10164106
OpenAlexW4323072971

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.