Evidence map›Paper›PMID 36871116›Full record

ArticleActa diabetologica2023

Metabolic control during the first two years of the COVID-19 pandemic in pediatric patients with type 1 diabetes: results from the German DPV initiative.

Johanna Hammersen, Sascha R Tittel, Semik Khodaverdi, Felix Reschke, Monika Flury, Ulrike Menzel, Kirsten Mönkemöller, Thomas Meissner, Beate Karges, Reinhard W Holl

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Article in Acta diabetologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Johanna Hammersen *Department of Pediatrics, University Hospital Erlangen, Loschgestr. 15, 91054, Erlangen, Germany. johanna.hammersen@uk-erlangen.de.ORCID http://orcid.org/0000-0001-8821-5775
Sascha R Tittel *Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.
Semik KhodaverdiClinic for Children and Adolescent Medicine, Clinical Centre Hanau, Hanau, Germany.
Felix ReschkeDiabetes Center for Children and Adolescents, Children's Hospital Auf Der Bult, Hannover, Germany.
Monika FluryChildren's Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Ulrike MenzelDepartment of Paediatric Endocrinology, AKK Altonaer Kinderkrankenhaus, Hamburg, Germany.
Kirsten MönkemöllerDepartment of Pediatrics, Kinderkrankenhaus Amsterdamer Strasse, Cologne, Germany.
Thomas MeissnerDepartment of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital, Duesseldorf, Germany.
Beate KargesDivision of Endocrinology and Diabetology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Reinhard W HollInstitute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.

Funding

German Center for Diabetes Research 82DZD14E1GGerman Diabetes Foundation FP-0446-2022
6 · The paper itself

Abstract

aimTo assess effects of the SARS-CoV2 pandemic on metabolic control in youth with type 1 diabetes (T1D) in Germany in a population-based analysis.

methodsData from 33,372 pediatric T1D patients from the Diabetes Prospective Follow-up (DPV) registry, with face-to-face visits or telemedicine contacts in the years 2019-2021, were available. Datasets from eight time periods between March 15, 2020, and December 31, 2021, according to SARS-CoV2 incidence waves, were compared to those from five control time periods. Parameters of metabolic control were assessed with adjustment for sex, age, diabetes duration, and repeated measurements. Laboratory-measured HbA1c values and those estimated from CGM were aggregated into a combined glucose indicator (CGI).

resultsThere was no clinically relevant difference in metabolic control between pandemic and control time periods with adjusted CGI values ranging from 7.61% [7.60-7.63] (mean [95% confidence interval (CI)]) in the third quarter of 2019 to 7.83% [7.82-7.85] in the time period from January 1 to March 15 2020, in the other control periods, and during the pandemic, CGI values lay between these values. BMI-SDS rose during the pandemic from 0.29 [0.28-0.30] (mean [95% CI]) in the third quarter of 2019 to 0.40 [0.39-0.41] during the fourth wave. Adjusted insulin dose rose during the pandemic. Event rates for hypoglycemic coma and diabetic ketoacidosis remained unchanged.

conclusionsWe found no clinically relevant change of glycemic control or incidence of acute diabetes complications during the pandemic. The observed BMI increase may represent an important health risk for youth with T1D.

Indexed as

COVID-19Diabetes Mellitus, Type 1AdolescentBlood GlucoseChildGlucoseHumansPandemicsProspective StudiesRNA, ViralSARS-CoV-2Blood GlucoseGlucoseRNA, ViralLockdownMetabolic controlPediatric diabetesSARS-CoV2 pandemic

Identifiers

PMID36871116
PMCPMC9985474

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.