Evidence map›Paper›PMID 36871077›Full record

ArticleNature communications2023

Structural basis of HIV-1 maturation inhibitor binding and activity.

Sucharita Sarkar, Kaneil K Zadrozny, Roman Zadorozhnyi, Ryan W Russell, Caitlin M Quinn, Alex Kleinpeter, Sherimay Ablan, Hamed Meshkin, Juan R Perilla, Eric O Freed and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Mechanisms of HIV-1 assembly, release and maturation.Nature reviews. Microbiology · 2026
    Review
  2. Synthesis ofMagnetic resonance in chemistry : MRC · 2026
    Article
  3. Article
  4. Unraveling the maturation pathway of a eukaryotic virus through cryo-EM.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. OPTO: Automated Optimization for Solid-State NMR Spectroscopy.Journal of the American Chemical Society · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Low power supercycled TPPM decoupling.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024
    Article
  15. Solid-State NMRJournal of magnetic resonance (San Diego, Calif. : 1997) · 2024
    Article
  16. High-efficiency low-powerJournal of magnetic resonance (San Diego, Calif. : 1997) · 2024
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Sucharita SarkarDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA.
Kaneil K ZadroznyDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Roman ZadorozhnyiDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA.
Ryan W RussellDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA.ORCID 0000-0002-3599-133X
Caitlin M QuinnDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA.ORCID 0000-0001-6172-7324
Alex KleinpeterHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702-1201, USA.ORCID 0000-0001-5630-1345
Sherimay AblanHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702-1201, USA.
Hamed MeshkinDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA.
Juan R PerillaDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA.ORCID 0000-0003-1171-6816
Eric O FreedHIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702-1201, USA.ORCID 0000-0003-3345-022X
Barbie K Ganser-PornillosDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA. bkg7q@virginia.edu.ORCID 0000-0001-6453-3891
Owen PornillosDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA. owp3a@virginia.edu.ORCID 0000-0001-9056-5002
Angela M GronenbornDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA. amg100@pitt.edu.ORCID 0000-0001-9072-3525
Tatyana PolenovaDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA. tpolenov@udel.edu.ORCID 0000-0002-0346-1131
University of Pittsburgh · USNational Cancer Institute · USUniversity of Virginia · USUniversity of Delaware · US

Funding

Project 3. IntegrationU54AI170791 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peter Cherepanov · 2022 to 2026
$30.6M
Technology Development 2: MAS NMR and dynamic nuclear polarization for HIV-1 structural biologyP50AI150481 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRONENBORN, ANGELA M. · 2019 to 2021
$14.1M
Inhibition of HIV-1 MaturationZIABC010778 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FREED, ERIC · 2009 to 2025
$9.7M
Mechanisms and Consequences of Reverse Transcription in HIV-1 CoresR01AI157843 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AIKEN, CHRISTOPHER R · 2021 to 2024
$2.8M
Molecular mechanisms of the CA-SP1 switch in HIV assembly and maturationR01AI129678 · NIAID · UNIVERSITY OF VIRGINIA · PI GANSER-PORNILLOS, BARBIE K., PORNILLOS, OWEN · 2017 to 2021
$2.3M
NIAID NIH HHS P50 AI150481NIAID NIH HHS R01 AI129678NIAID NIH HHS R01 AI157843NIAID NIH HHS U54 AI170791
6 · The paper itself

Abstract

HIV-1 maturation inhibitors (MIs), Bevirimat (BVM) and its analogs interfere with the catalytic cleavage of spacer peptide 1 (SP1) from the capsid protein C-terminal domain (CA

Indexed as

HIV-1TriterpenesCapsidCapsid ProteinsCatalysisPentacyclic TriterpenesSuccinatesbevirimatCapsid ProteinsPentacyclic TriterpenesSuccinatesTriterpenes

Identifiers

PMID36871077
PMCPMC9985623
OpenAlexW4323050140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.