Evidence map›Paper›PMID 36871034›Full record

ArticleNPJ Parkinson's disease2023

The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson's disease data.

Hampton L Leonard, Ruqaya Murtadha, Alejandro Martinez-Carrasco, Alina Jama, Amica Corda Müller-Nedebock, Ana-Luisa Gil-Martinez, Anastasia Illarionova, Anni Moore, Bernabe I Bustos, Bharati Jadhav and 47 more

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In one paragraph

Article in NPJ Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

57 authors.

Hampton L LeonardLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. leonardhl@nih.gov.ORCID http://orcid.org/0000-0003-2390-8110
Ruqaya MurtadhaCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Alejandro Martinez-CarrascoDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Alina JamaDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.
Amica Corda Müller-NedebockDivision of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Ana-Luisa Gil-MartinezDepartment of Neurodegenerative Disease, University College London, London, UK.
Anastasia IllarionovaGerman Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.ORCID http://orcid.org/0000-0002-1711-7155
Anni MooreLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1953-6449
Bernabe I BustosThe Ken & Ruth Davee Department of Neurology and Simpson Querrey Center of Neurogenetics, Feinberg Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.ORCID http://orcid.org/0000-0003-2679-9503
Bharati JadhavDepartment of Genetics and Genomic Sciences and Mindich Child Health and Development Institute, Icahn School of Medicine at Mount, Hess Center for Science and Medicine, New York, NY, 10029, USA.
Brook HuxfordPreventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-5908-6983
Catherine StormDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0003-4957-1712
Clodagh TownsDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0001-8418-6241
Dan VitaleLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Devina ChettyDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.
Eric YuDepartment of Human Genetics, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-3525-4564
Francis P GrennLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Gabriela SalazarINNCOSYS, Col. Morelos Second Section, 50120, Toluca de Lerdo, México.
Geoffrey RateauInstitut du Cerveau - Institute of Brain and Spine (ICM), Hôpital Pitié, 47 Bd de l'Hôpital, 75013, Paris, France.
Hirotaka IwakiLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Inas ElsayedFaculty of pharmacy, University of Gezira, Wad Medani, P.O. Box 20, Sudan.ORCID http://orcid.org/0000-0003-4646-8218
Isabelle Francesca FootePreventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Zuné Jansen van RensburgDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.
Jonggeol Jeff KimLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Jie YuanCenter for Advanced Parkinson Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Julie LakeLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3441-2455
Kajsa BrolinTranslational Neurogenetics Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0003-4832-922X
Konstantin SenkevichDepartment of Human Genetics, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-3407-5716
Lesley WuDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Manuela M X TanDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0001-5835-669X
María Teresa PeriñánUnidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Mary B MakariousLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-7978-1051
Michael TaLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Nikita Simone PillaySouth African National Bioinformatics Institute (SANBI), South African Medical Research Council Bioinformatics Unit, University of the Western Cape, Bellville, South Africa.ORCID http://orcid.org/0000-0002-9058-0920
Oswaldo Lorenzo BetancorVeterans Affairs Puget Sound Health Care System, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5607-8363
Paula R Reyes-PérezLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de, México, Juriquilla, México.
Pilar Alvarez JerezLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Prabhjyot SainiDepartment of Human Genetics, McGill University, Montreal, QC, Canada.
Rami Al-OuranDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, 77030, USA.
Ramiya SivakumarUniversity of Southern California, Los Angeles, CA, 90007, USA.
Raquel RealDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0001-8117-742X
Regina H ReynoldsSouth African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-6470-7919
Ruifneg HuCenter for Advanced Parkinson Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Shameemah AbrahamsDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.
Shilpa C RaoDepartment of Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Tarek AntarLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Thiago Peixoto LealDepartment of Genomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Vassilena IankovaDepartment of Neurology With Friedrich Baur Institut, University Hospital of Ludwig-Maximilians-Universität München, Munich, Germany.
William J ScottonSouth African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0003-0607-3190
Yeajin SongLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Andrew SingletonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5606-700X
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Sumit DeyPreventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-9087-4486
Sara Bandres-CigaLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Cornelis BlauwendraatLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9358-8111
Alastair J NoycePreventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0003-3027-5497
on behalf of The International Parkinson Disease Genomics Consortium (IPDGC) and The Global Parkinson’s Genetics Program (GP2)

Funding

Genome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6M
Intramural NIH HHS Z01 AG000949U.S. Department of Health & Human Services | National Institutes of Health (NIH) ZO1 AG000535U.S. Department of Health & Human Services | National Institutes of Health (NIH) ZO1 AG000949
6 · The paper itself

Abstract

Open science and collaboration are necessary to facilitate the advancement of Parkinson's disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to generate resources and creative solutions to problems. These events can be used as training and networking opportunities, thus we coordinated a virtual 3-day hackathon event, during which 49 early-career scientists from 12 countries built tools and pipelines with a focus on PD. Resources were created with the goal of helping scientists accelerate their own research by having access to the necessary code and tools. Each team was allocated one of nine different projects, each with a different goal. These included developing post-genome-wide association studies (GWAS) analysis pipelines, downstream analysis of genetic variation pipelines, and various visualization tools. Hackathons are a valuable approach to inspire creative thinking, supplement training in data science, and foster collaborative scientific relationships, which are foundational practices for early-career researchers. The resources generated can be used to accelerate research on the genetics of PD.

Identifiers

PMID36871034
PMCPMC9984758

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.