ArticleBMC chemistry2023
A green protocol ball milling synthesis of dihydropyrano[2,3-c]pyrazole using nano-silica/aminoethylpiperazine as a metal-free catalyst.
Article in BMC chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Ball-mill-assisted mechanochemical approaches for heterocyclic compound synthesis (2015-2024).Molecular diversity · 2026Review
- B(iii)-catalyzed synthesis of spirooxindole and dihydro-2-oxopyrrole under solventless conditions in a ball mill, along with DFT computations.RSC advances · 2025Article
- Nanao/organocatalyat SiOBMC chemistry · 2025Article
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Abstract
backgroundBall mill is an effective, and green method for the synthesis of heterocyclic compounds in very good yields. This method is a simple, economical, and environmentally friendly process. In this work, an efficient approach for the synthesis of pyranopyrazoles (PPzs) using ball milling and metal-free nano-catalyst (Nano-silica/aminoethylpiperazine), under solvent-free conditions was reported.
resultsThe new nano-catalyst silica/aminoethylpiperazine was prepared by immobilization of 1-(2-aminoethyl)piperazine on nano-silica chloride. The structure of the prepared nano-catalyst was identified by FT-IR, FESEM, TGA, EDX, EDS-map, XRD, and pH techniques. This novel nano-catalyst was used for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives under ball milling and solvent-free conditions.
conclusionsUnlike other pyranopyrazoles synthesis reactions, this method has advantages including short reaction time (5-20 min), room temperature, and relatively high efficiency, which makes this protocol very attractive for the synthesis of pyranopyrazoles derivatives.
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