Evidence map›Paper›PMID 36870874›Full record

ReviewVaccine2023

A research and development (R&D) roadmap for broadly protective coronavirus vaccines: A pandemic preparedness strategy.

Kristine A Moore, Tabitha Leighton, Julia T Ostrowsky, Cory J Anderson, Richard N Danila, Angela K Ulrich, Eve M Lackritz, Angela J Mehr, Ralph S Baric, Norman W Baylor and 9 more

Open access · hybridAbstract readReview
In one paragraph

Review in Vaccine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  11. Article
  12. SARS-CoV-2 MSLAS discovery : advancing life sciences R & D · 2024
    Article
  13. Review
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 3 countries.

Kristine A MooreCenter for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, Minnesota, USA; Center for Infectious Disease Research and Policy, C315 Mayo Memorial Building, MMC 263, 420 Delaware Street, SE, Minneapolis, Minnesota 55455, USA. Electronic address: kamoore@umn.edu.
Tabitha LeightonCenter for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, Minnesota, USA.
Julia T OstrowskyCenter for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, Minnesota, USA.
Cory J AndersonCenter for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, Minnesota, USA.
Richard N DanilaMinnesota Department of Health, St. Paul, Minnesota, USA.
Angela K UlrichCenter for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, Minnesota, USA.
Eve M LackritzCenter for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, Minnesota, USA.
Angela J MehrCenter for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, Minnesota, USA.
Ralph S BaricUniversity of North Carolina, Chapel Hill, North Carolina, USA.
Norman W BaylorBiologics Consulting Group, Inc., Alexandria, Virginia, USA.
Bruce G GellinThe Rockefeller Foundation, Washington, DC, USA.
Jennifer L GordonNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Florian KrammerDepartment of Microbiology, Department of Pathology, Molecular and Cell-Based Medicine, and Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Stanley PerlmanUniversity of Iowa, Iowa City, Iowa, USA.
Helen V ReesWits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Melanie SavilleCoalition for Epidemic Preparedness Innovations, London, United Kingdom.
Charlotte L WellerWellcome Trust, London, United Kingdom.
Michael T OsterholmCenter for Infectious Disease Research and Policy, University of Minnesota, Minneapolis, Minnesota, USA.
Coronavirus Vaccines R&D Roadmap Taskforce
University of Minnesota · USIcahn School of Medicine at Mount Sinai · USMinnesota Department of Health · USNational Institute of Allergy and Infectious Diseases · USRockefeller Foundation · USUniversity of Iowa · USUniversity of North Carolina at Chapel Hill · USUniversity of the Witwatersrand · ZAWellcome Trust · GB

Funding

SDMC: HIV Vaccine Trials NetworkUM1AI068635 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Peter B. Gilbert, Yunda Huang · 2011 to 2026
$385.9M
Gates Foundation INV-040729NIAID NIH HHS UM1 AI068635
6 · The paper itself

Abstract

Broadly protective coronavirus vaccines are an important tool for protecting against future SARS-CoV-2 variants and could play a critical role in mitigating the impact of future outbreaks or pandemics caused by novel coronaviruses. The Coronavirus Vaccines Research and Development (R&D) Roadmap (CVR) is aimed at promoting the development of such vaccines. The CVR, funded by the Bill & Melinda Gates Foundation and The Rockefeller Foundation, was generated through a collaborative and iterative process, which was led by the Center for Infectious Disease Research and Policy (CIDRAP) at the University of Minnesota and involved 50 international subject matter experts and recognized leaders in the field. This report summarizes the major issues and areas of research outlined in the CVR and identifies high-priority milestones. The CVR covers a 6-year timeframe and is organized into five topic areas: virology, immunology, vaccinology, animal and human infection models, and policy and finance. Included in each topic area are key barriers, gaps, strategic goals, milestones, and additional R&D priorities. The roadmap includes 20 goals and 86 R&D milestones, 26 of which are ranked as high priority. By identifying key issues, and milestones for addressing them, the CVR provides a framework to guide funding and research campaigns that promote the development of broadly protective coronavirus vaccines.

Indexed as

COVID-19VaccinesAnimalsCOVID-19 VaccinesHumansPandemicsResearchSARS-CoV-2COVID-19 VaccinesVaccinesBroadly protective coronavirus vaccinesCoronavirusCoronavirus vaccinesCOVID-19 vaccinesPandemic preparednessRoadmapVaccine research

Identifiers

PMID36870874
PMCPMC9941884
OpenAlexW4321453930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.