Evidence map›Paper›PMID 36870804›Full record

ReviewDifferentiation; research in biological diversity

Corneal epithelial development and homeostasis.

Shivalingappa K Swamynathan, Sudha Swamynathan

Abstract readReview
In one paragraph

Review in Differentiation; research in biological diversity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Tea tree oil action on human corneal epithelial cells biological activity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Characterization of Corneal Defects in ATG7-Deficient Mice.International journal of molecular sciences · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shivalingappa K SwamynathanDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. Electronic address: SS65@USF.edu.
Sudha SwamynathanDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yuanyuan Chen · 1989 to 2026
$17.8M
Ocular Surface Functions of KLF4 and KLF5R01EY026533 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI SWAMYNATHAN, SHIVALINGAPPA KOTTUR · 2016 to 2025
$3.4M
Ocular surface functions of SLURP1R01EY031684 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI SWAMYNATHAN, SHIVALINGAPPA KOTTUR · 2021 to 2025
$2.0M
NEI NIH HHS P30 EY008098NEI NIH HHS R01 EY026533NEI NIH HHS R01 EY031684
6 · The paper itself

Abstract

The corneal epithelium (CE), the most anterior cellular structure of the eye, is a self-renewing stratified squamous tissue that protects the rest of the eye from external elements. Each cell in this exquisite three-dimensional structure needs to have proper polarity and positional awareness for the CE to serve as a transparent, refractive, and protective tissue. Recent studies have begun to elucidate the molecular and cellular events involved in the embryonic development, post-natal maturation, and homeostasis of the CE, and how they are regulated by a well-coordinated network of transcription factors. This review summarizes the status of related knowledge and aims to provide insight into the pathophysiology of disorders caused by disruption of CE development, and/or homeostasis.

Indexed as

CorneaEpithelium, CornealHomeostasisTranscription FactorsTranscription FactorsCorneaDevelopmentEMTEpitheliumHomeostasisKLF4OSSNPlane of divisionPolarity

Identifiers

PMID36870804
PMCPMC10363238

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.