Evidence map›Paper›PMID 36870457›Full record

ReviewNeurobiology of disease2023

The role of innate lymphocytes in regulating brain and cognitive function.

Youwen Si, Yuanyue Zhang, Kristen Zuloaga, Qi Yang

Open access · goldAbstract readReview
In one paragraph

Review in Neurobiology of disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Immune checkpoint inhibition perturbs neuro-immune homeostasis and impairs cognitive function.Journal of experimental & clinical cancer research : CR · 2025
    Article
  4. Article
  5. CNS Resident Innate Immune Cells: Guardians of CNS Homeostasis.International journal of molecular sciences · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Youwen SiChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Yuanyue ZhangChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Kristen ZuloagaDepartment of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, NY, 12208, USA.
Qi YangChild Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA; Rutgers Institute for Translational Medicine and Science, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA; Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA. Electronic address: qy117@rwjms.rutgers.edu.
Rutgers, The State University of New Jersey · USAlbany Medical Center Hospital · USJohnson University · US

Funding

Investigating the Functional Impact of AD Risk Genes on Neuro-Vascular InteractionsU01AG072464 · NIA · REGENERATIVE RESEARCH FOUNDATION · PI HARARI, OSCAR, KAMPMANN, MARTIN · 2021 to 2025
$8.7M
Metabolic and Hormonal Mechanisms of VCIDR01NS110749 · NINDS · ALBANY MEDICAL COLLEGE · PI Kristen Leanne Zuloaga · 2019 to 2026
$4.3M
Function and regulation of mucosal associated invariant T cells in the lungR01HL155021 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI YANG, QI · 2021 to 2025
$2.8M
Innate Lymphoid Cell AgingR01AG057782 · NIA · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI YANG, QI · 2017 to 2021
$1.7M
Development and function of inflammatory innate lymphoid cellsR01HL137813 · NHLBI · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI YANG, QI · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL137813NHLBI NIH HHS R01 HL155021NIA NIH HHS R01 AG057782NIA NIH HHS U01 AG072464NINDS NIH HHS R01 NS110749
6 · The paper itself

Abstract

Mounting evidence indicates complex interaction between the immune system and the nervous system, challenging the traditional view about the immune privilege of the brain. Innate lymphoid cells (ILCs) and innate-like T cells are unique families of immune cells that functionally mirror traditional T cells but may function via antigen- and T cell antigen receptor (TCR)-independent mechanisms. Recent work indicates that various ILCs and innate-like T cell subsets are present in the brain barrier tissue, where they play important roles in regulating brain barrier integrity, brain homeostasis and cognitive function. In this review, we discuss recent advances in understanding the intricate roles for innate and innate-like lymphocytes in regulating brain and cognitive function.

Indexed as

Immunity, InnateLymphocytesBrainCognitionT-LymphocytesBrainCognitiveInnate-like T cellsInnate lymphoid cells

Identifiers

PMID36870457
PMCPMC11194859
OpenAlexW4322761442

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.