Evidence map›Paper›PMID 36870375›Full record

ArticleFree radical biology & medicine2023

Activation of neuronal NADPH oxidase NOX2 promotes inflammatory neurodegeneration.

Dezhen Tu, Ravikanth Velagapudi, Yun Gao, Jau-Shyong Hong, Hui Zhou, Hui-Ming Gao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Dezhen TuState Key Laboratory of Pharmaceutical Biotechnology, Ministry of Education Key Laboratory of Model Animal for Disease Study, Institute for Brain Sciences, Jiangsu Key Laboratory of Molecular Medicine, Model Animal Research Center, Medical School of Nanjing University, 12 Xuefu Road, Nanjing, Jiangsu Province, 210061, China; Neurobiology Laboratory, Neuropharmacology Section, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Ravikanth VelagapudiNeurobiology Laboratory, Neuropharmacology Section, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Yun GaoState Key Laboratory of Pharmaceutical Biotechnology, Ministry of Education Key Laboratory of Model Animal for Disease Study, Institute for Brain Sciences, Jiangsu Key Laboratory of Molecular Medicine, Model Animal Research Center, Medical School of Nanjing University, 12 Xuefu Road, Nanjing, Jiangsu Province, 210061, China; Neurobiology Laboratory, Neuropharmacology Section, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Jau-Shyong HongNeurobiology Laboratory, Neuropharmacology Section, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Hui ZhouNeurobiology Laboratory, Neuropharmacology Section, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, 27709, USA; Department of Occupational and Environmental Health Sciences, Peking University, Beijing, 100191, China. Electronic address: hardhui@126.com.
Hui-Ming GaoState Key Laboratory of Pharmaceutical Biotechnology, Ministry of Education Key Laboratory of Model Animal for Disease Study, Institute for Brain Sciences, Jiangsu Key Laboratory of Molecular Medicine, Model Animal Research Center, Medical School of Nanjing University, 12 Xuefu Road, Nanjing, Jiangsu Province, 210061, China. Electronic address: gaohm@nju.edu.cn.
National Institute of Environmental Health Sciences · USModel Animal Research Center · CNNanjing University · CNNational Institutes of Health · USPeking University · CN

Funding

ROLES OF BRAIN NEUROIMMUNE SYSTEM IN NEURODEGENERATIONZ01ES090082 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HONG, JAU-SHYONG SHYONG · 1997 to 2008
$3.9M
Intramural NIH HHS Z01 ES090082
6 · The paper itself

Abstract

Strong evidence indicates critical roles of NADPH oxidase (a key superoxide-producing enzyme complex during inflammation) in activated microglia for mediating neuroinflammation and neurodegeneration. However, little is known about roles of neuronal NADPH oxidase in neurodegenerative diseases. This study aimed to investigate expression patterns, regulatory mechanisms and pathological roles of neuronal NADPH oxidase in inflammation-associated neurodegeneration. The results showed persistent upregulation of NOX2 (gp91

Indexed as

Neuroinflammatory DiseasesParkinson DiseaseAnimalsCells, CulturedDopaminergic NeuronsInflammationLipopolysaccharidesMiceMice, Inbred C57BLMicrogliaNADPH Oxidase 2NADPH OxidasesReactive Oxygen SpeciesCybb protein, mouseLipopolysaccharidesNADPH Oxidase 2NADPH OxidasesReactive Oxygen SpeciesMicrogliaMitochondrial dysfunctionNeurodegenerationNeuronal NADPH oxidaseNOX2Oxidative stress

Identifiers

PMID36870375
PMCPMC10164140
OpenAlexW4322766620

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.