Evidence map›Paper›PMID 36869977›Full record

ArticleInternational ophthalmology2023

Inner retinal layers' alterations of the microvasculature in early stages of Parkinson's disease: a cross sectional study.

Evita Evangelia Christou, Spiridon Konitsiotis, Konstantinos Pamporis, Alexandros Giannakis, Christoforos Asproudis, Maria Stefaniotou, Ioannis Asproudis

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Article in International ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Retinal microvascular alterations in Parkinson's disease: visual analysis and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Evita Evangelia ChristouDepartment of Ophthalmology, Faculty of Medicine, University Hospital of Ioannina, 45110, Ioannina, Greece. evitachristou@gmail.com.ORCID http://orcid.org/0000-0002-7959-4854
Spiridon KonitsiotisDepartment of Neurology, Faculty of Medicine, University Hospital of Ioannina, Ioannina, Greece.
Konstantinos PamporisDepartment of Hygiene, Social-Preventive Medicine & Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece.
Alexandros GiannakisDepartment of Neurology, Faculty of Medicine, University Hospital of Ioannina, Ioannina, Greece.
Christoforos AsproudisDepartment of Ophthalmology, Faculty of Medicine, University Hospital of Ioannina, 45110, Ioannina, Greece.
Maria StefaniotouDepartment of Ophthalmology, Faculty of Medicine, University Hospital of Ioannina, 45110, Ioannina, Greece.
Ioannis AsproudisDepartment of Ophthalmology, Faculty of Medicine, University Hospital of Ioannina, 45110, Ioannina, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate microcirculation characteristics of the inner retinal layers at the macula and the peripapillary area using Optical Coherence Tomography Angiography (OCT-A) of patients in early stages of Parkinson's disease (PD).

methods32 PD patients and 46 age- and gender-matched healthy controls were included in this cross sectional study. OCT-A imaging was performed to analyze microcirculation characteristics at each separate macular region (fovea, parafovea, and perifovea) and the peripapillary area of the inner retinal layers.

resultsIndividuals with PD had significantly lower parafoveal, perifoveal and total vessel density (VD) in the superficial capillary plexus (SCP) than controls (all p < 0.001), while foveal VD was higher in PD eyes than that of controls, though not statistically significant. Similarly, individuals with PD had significantly lower parafoveal, perifoveal and total perfusion in the SCP than control eyes (all p < 0.001), while foveal perfusion was significantly higher in PD eyes than that of controls (p = 0.008). PD eyes had significantly smaller FAZ area and perimeter accompanied by decreased circularity at the SCP as compared to controls (all p < 0.001). Concerning the peripapillary area, individuals with PD had significantly lower radial peripapillary capillary perfusion density and flux index at the SCP than controls (all p < 0.001). All p values remained statistically significant even after using the Bonferroni correction for multiple comparisons, except for that of foveal perfusion.

conclusionsOur study indicates alterations of the inner retinal layers at the macula and the peripapillary area at the preliminary stages of PD. OCT-A parameters could potentially comprise imaging biomarkers for PD screening and improve the diagnostic algorithms.

Indexed as

Parkinson DiseaseRetinal VesselsCross-Sectional StudiesFluorescein AngiographyHumansMicrovesselsTomography, Optical CoherenceMaculaMicrocirculationOptical coherence tomography angiographyParkinson’s diseaseRadial peripapillary capillary plexus

Identifiers

PMID36869977

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.