Evidence map›Paper›PMID 36869890›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2023

Persistence of vascular empty sleeves in choroidal neovascularization after VEGF therapy in both animal models and humans.

Iori Wada, Shintaro Nakao, Yosuke Fukuda, Satomi Shiose, Atsunobu Takeda, Ram Kannan, Koh-Hei Sonoda

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Iori WadaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shintaro NakaoDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. s.nakao.dk@juntendo.ac.jp.ORCID http://orcid.org/0000-0003-4200-0052
Yosuke FukudaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Satomi ShioseDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Atsunobu TakedaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ram KannanDoheny Eye Institute, Pasadena, CA, USA.
Koh-Hei SonodaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kyushu University · JPUniversity of California, Los Angeles · US

Funding

JSPS KAKENHI 20K09829NIH HHS EY30141
6 · The paper itself

Abstract

purposeChoroidal neovascularization (CNV) often recurs during anti-vascular endothelial growth factor (VEGF) therapy; however, little is known about the mechanism of vascular regrowth. Vascular regrowth along the empty sleeves of basement membranes was proposed as a mechanism for recurrence after the reversal of VEGF inhibition in tumors. This study investigated whether the proposed mechanism is involved in CNV during VEGF therapy.

methodsWe made two observations using a mice model, as well as patients with CNV. Laser-induced CNV mice were used to examine the vascular empty sleeves of the basement membrane and CNV with the immunohistochemistry of type IV collagen and CD31, respectively. A retrospective cohort study included 17 eyes from 17 patients with CNV treated with anti-VEGF treatment. Vascular regrowth during anti-VEGF treatment was assessed using optical coherence tomography angiography (OCTA).

resultsIn the CNV mouse model, the CD31

conclusionsParts of CNV regrowth may occur along the vascular empty sleeve, which remain after anti-VEGF treatment.

Indexed as

Angiogenesis InhibitorsChoroidal NeovascularizationAnimalsCollagen Type IVDisease Models, AnimalFluorescein AngiographyHumansIntravitreal InjectionsMiceRetrospective StudiesTomography, Optical CoherenceVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsAngiogenesis InhibitorsCollagen Type IVVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsAge-related macular degenerationChoroidal neovascularizationMice modelOCTAVascular empty sleeveVascular endothelial growth factor

Identifiers

PMID36869890
OpenAlexW4323050214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.