Evidence map›Paper›PMID 36869878›Full record

Trial reportJournal of thrombosis and thrombolysis2023

Layered plaque and plaque volume in patients with acute coronary syndromes.

Haruhito Yuki, Daisuke Kinoshita, Keishi Suzuki, Takayuki Niida, Akihiro Nakajima, Lena Marie Seegers, Rocco Vergallo, Francesco Fracassi, Michele Russo, Luca Di Vito and 6 more

2 registry-linked trialsOpen access · greenAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of thrombosis and thrombolysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01110538 completednot on this map

The Massachusetts General Hospital Optical Coherence Tomography Registry

TypeobservationalSponsorIk-Kyung Jang, MD, PhDRan2010 to 2019Enrolled2,714ConditionsCoronary Artery Disease
NCT03479723 completednot on this map

Identification of Predictors for Coronary Plaque Erosion in Patients With Acute Coronary Syndrome

Typeobservational_patient_registrySponsorMassachusetts General HospitalRan2017 to 2024Enrolled1,793ConditionsAcute Coronary Syndrome
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Coronary plaque healing: a safety net or a hazard indicator?Journal of thrombosis and thrombolysis · 2026
    Review
  2. CVIT 2025 clinical expert consensus document on intravascular ultrasound.Cardiovascular intervention and therapeutics · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 6 countries.

Haruhito YukiCardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street | GRB 800 |, 02114, Boston, MA, USA.
Daisuke KinoshitaCardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street | GRB 800 |, 02114, Boston, MA, USA.
Keishi SuzukiCardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street | GRB 800 |, 02114, Boston, MA, USA.
Takayuki NiidaCardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street | GRB 800 |, 02114, Boston, MA, USA.
Akihiro NakajimaInterventional Cardiology Unit, New Tokyo Hospital, 1271 Wanagaya, Matsudo, Chiba, 270-2232, Japan.
Lena Marie SeegersCardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street | GRB 800 |, 02114, Boston, MA, USA.
Rocco VergalloInterventional Cardiology Unit, Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.
Francesco FracassiDepartment of Cardiology, Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
Michele RussoDepartment of Cardiology, S. Maria dei Battuti Hospital, AULSS 2 Veneto, Conegliano, Italy.
Luca Di VitoCardiology Unit, C. and G. Mazzoni Hospital, Via degli Iris 1, 63100, Ascoli Piceno, Italy.
Krzysztof BryniarskiInstitute of Cardiology, Department of Interventional Cardiology, Jagiellonian University Medical College, John Paul II Hospital, Krakow, Poland.
Iris McNultyCardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street | GRB 800 |, 02114, Boston, MA, USA.
Hang LeeBiostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Tsunekazu KakutaDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura, Ibaraki, Japan.
Sunao NakamuraInterventional Cardiology Unit, New Tokyo Hospital, 1271 Wanagaya, Matsudo, Chiba, 270-2232, Japan. boss0606@pluto.plala.or.jp.
Ik-Kyung JangCardiology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street | GRB 800 |, 02114, Boston, MA, USA. ijang@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-5796-3006
Harvard University · USNew Tokyo Hospital · JPAgostino Gemelli University Polyclinic · ITJagiellonian University · PLKyung Hee University · KROspedale di Santa Maria dei Battuti · ITSt Bartholomew's Hospital · GBTsuchiura Kyodo General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLayered plaque is a signature of previous subclinical plaque destabilization and healing. Following plaque disruption, thrombus becomes organized, resulting in creation of a new layer, which might contribute to rapid step-wise progression of the plaque. However, the relationship between layered plaque and plaque volume has not been fully elucidated.

methodsPatients who presented with acute coronary syndromes (ACS) and underwent pre-intervention optical coherence tomography (OCT) and intravascular ultrasound (IVUS) imaging of the culprit lesion were included. Layered plaque was identified by OCT, and plaque volume around the culprit lesion was measured by IVUS.

resultsAmong 150 patients (52 with layered plaque; 98 non-layered plaque), total atheroma volume (183.3 mm

conclusionLayered plaques, compared to non-layered plaques, had significantly greater plaque volume and lipid index. These results indicate that plaque disruption and the subsequent healing process significantly contribute to plaque progression at the culprit lesion in patients with ACS. CLINICAL

trial registrationhttp://www. CLINICALTRIALS: gov , NCT01110538, NCT03479723, UMIN000041692.

Indexed as

Acute Coronary SyndromeCoronary Artery DiseasePlaque, AtheroscleroticCoronary AngiographyCoronary VesselsHumansLipidsTomography, Optical CoherenceUltrasonography, InterventionalLipidsAcute coronary syndromesIntravascular ultrasoundLayered plaqueOptical coherence tomographyPlaque volume

Identifiers

PMID36869878
OpenAlexW4323050211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.