ArticleJournal of Crohn's & colitis2023
Diagnosis and Clinical Features of Perianal Lesions in Newly Diagnosed Crohn's Disease: Subgroup Analysis from Inception Cohort Registry Study of Patients with Crohn's Disease (iCREST-CD).
Article in Journal of Crohn's & colitis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Long-term safety and efficacy of darvadstrocel for complex perianal fistulas in Japanese adults with Crohn's disease: 3-year follow-up results.Crohn's & colitis 360 · 2026Article
- When nothing else matters: proctectomy for complex perianal Crohn's disease-indications, timing, techniques, and outcomes.Techniques in coloproctology · 2026Review
- Magnetic resonance imaging to differentiate between Crohn's disease-associated and cryptoglandular perianal fistula.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Scrotal abscesses in perianal Crohn's disease: a retrospective cohort study of clinical presentation, management, and outcomes.Techniques in coloproctology · 2026Article
- A predictive model for differentiating perianal Crohn's disease activity with 3D transrectal ultrasonography.European radiology · 2026Article
- Real-world outcomes of ustekinumab, vedolizumab, and tumor necrosis factor inhibitors in very-early-onset inflammatory bowel disease: a multi-center cohort study.Journal of gastroenterology · 2026Article
- Development and Validation of an Ileocolonoscopy-Based Nomogram for Predicting Perianal Penetrating Complications in Patients with Crohn's Disease.Journal of inflammation research · 2026Article
- Impact of Perianal Inflammatory Lesions in Crohn's Disease Patients with Anorectal Cancer.Journal of the anus, rectum and colon · 2026Article
- Real-world use of biologics during the first year of treatment for newly diagnosed Crohn's disease in Japan: a claims analysis from 2010 to 2021.Intestinal research · 2026Article
- Non-Fistulizing Perianal Disease in Crohn's Disease: Clinical Significance, Pathogenesis, and Management Strategies.Journal of clinical medicine · 2025Review
- Clinical Features and Short-Term Disease Progression of Asymptomatic Perianal Fistulizing Crohn's Disease.Digestion · 2025Article
- Association of appendectomy with disease phenotype and clinical course in Crohn's disease: results from two cohorts.Techniques in coloproctology · 2025Article
- Induction Efficacy and Safety of Upadacitinib for Active Crohn's Disease in Japanese Patients: A Multicenter Retrospective Study.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Unraveling the link between inflammatory bowel disease and perianal abscess: insights from bidirectional and multivariable Mendelian randomization study.BMC gastroenterology · 2025Article
- Patients' Attitudes to Magnetic Resonance Imaging in Perianal Fistulizing Crohn's Disease: A Global Survey.Crohn's & colitis 360 · 2025Article
- Management of Anal Fistula with Crohn's Disease.Journal of the anus, rectum and colon · 2025Review
- Trajectory of Self-Reported Pain and Association with Quality of Life in Patients with Perianal Abscesses After Surgery.Journal of pain research · 2025Article
- Perianal fistulizing lesions of Crohn's disease are associated with long-term behavior and its transition: a Chinese cohort study.Intestinal research · 2024Article
- Long-Term Outcome of Surgery for Perianal Crohn's Fistula.Medicina (Kaunas, Lithuania) · 2024Article
- Safety and Effectiveness of Ustekinumab for Crohn's Disease With Perianal Manifestations: Ad hoc Analysis Data From 1-Year Post-Marketing Surveillance Study in Japan.Crohn's & colitis 360 · 2024Article
Corrections and comments
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Authors and funding
29 authors at 20 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsPerianal lesion is a refractory phenotype of Crohn's disease [CD] with significantly diminished quality of life. We evaluated the clinical characteristics of perianal lesions in newly diagnosed CD patients and the impact of perianal lesions on the quality of life in Japanese patients with CD.
methodsPatients newly diagnosed with CD after June 2016 were included between December 2018 and June 2020 from the Inception Cohort Registry Study of Patients with CD [iCREST-CD].
resultsPerianal lesions were present in 324 [48.2%] of 672 patients with newly diagnosed CD; 71.9% [233/324] were male. The prevalence of perianal lesions was higher in patients aged <40 years vs ≥40 years, and it decreased with age. Perianal fistula [59.9%] and abscess [30.6%] were the most common perianal lesions. In multivariate analyses, male sex, age <40 years and ileocolonic disease location were significantly associated with a high prevalence of perianal lesions, whereas stricturing behaviour and alcohol intake were associated with low prevalence. Fatigue was more frequent [33.3% vs 21.6%] while work productivity and activity impairment-work time missed [36.3% vs 29.5%] and activity impairment [51.9% vs 41.1%] were numerically higher in patients with than those without perianal lesions.
conclusionsAt the time of CD diagnosis, approximately half of the patients had perianal lesions; perianal abscesses and perianal fistulas were the most common. Young age, male sex, disease location and behaviour were significantly associated with the presence of perianal lesions. The presence of perianal lesion was associated with fatigue and impairment of daily activities. CLINICAL TRIALS REGISTRY: University Hospital Medical Information Network Clinical Trials Registry System [UMIN-CTR, UMIN000032237].
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.