Evidence map›Paper›PMID 36869733›Full record

Trial reportSchizophrenia bulletin2023

Cognitive Remediation Works But How Should We Provide It? An Adaptive Randomized Controlled Trial of Delivery Methods Using a Patient Nominated Recovery Outcome in First-Episode Participants.

Til Wykes, Dominic Stringer, Janette Boadu, Rose Tinch-Taylor, Emese Csipke, Matteo Cella, Andrew Pickles, Paul McCrone, Clare Reeder, Max Birchwood and 11 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled TrialAdaptive Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06286202 (Integrative Neuro-social Cognitive Strategy Programme for Instilling REcovery), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06286202 narecruitingnot on this mapstarted 2024, after this paper: background citation

Integrative Neuro-social Cognitive Strategy Programme for Instilling REcovery (INSPIRE): a Community-Based Cognitive Remediation Trial

TypeinterventionalSponsorSingapore Institute of TechnologyRan2024 to 2027Enrolled160ConditionsSchizophrenia, Schizoaffective DisorderArmsCognitive Remediation: Adapted Neuropsychological and Education Approach to Remediation (NEAR), Standard Psychiatric Rehabilitation at Anglican Care Centers
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  13. International perspective on social cognition in schizophrenia: current stage and the next steps.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 1 country.

Til WykesInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-5881-8003
Dominic StringerInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Janette BoaduInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Rose Tinch-TaylorInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Emese CsipkeInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Matteo CellaInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-5701-0336
Andrew PicklesInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Paul McCroneSchool of Health Sciences, University of Greenwich, London, UK.
Clare ReederInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Max BirchwoodWarwick Medical School, University of Warwick, Coventry, UK.
David FowlerSchool of Psychology, University of Sussex, Brighton, UK.
Kathryn GreenwoodSchool of Psychology, University of Sussex, Brighton, UK.
Sonia JohnsonFaculty of Brain Sciences, University College London, London, UK.
Jesus PerezCambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Rosa RitunnanoWarwick Medical School, University of Warwick, Coventry, UK.
Andrew ThompsonWarwick Medical School, University of Warwick, Coventry, UK.
Rachel UpthegroveSchool of Psychology, University of Birmingham, Birmingham, UK.
Jon WilsonNorfolk and Suffolk NHS Foundation Trust, Norwich, UK.
Alex KennyPatient Advisory Board, King's College London, London, UK.
Iris IsokPatient Advisory Board, King's College London, London, UK.
Eileen M JoyceUCL Queen Square Institute of Neurology, University College London, London, UK.
King's College London · GBUniversity of Warwick · GBUniversity of Sussex · GBCambridgeshire and Peterborough NHS Foundation Trust · GBNational Hospital for Neurology and Neurosurgery · GBNorfolk and Suffolk NHS Foundation Trust · GBUniversity College London · GBUniversity of Birmingham · GBUniversity of Greenwich · GB

Funding

Department of Health IS-BRC-1215-20018Department of Health NF-SI-0514-10023Department of Health NF-SI-0617-10120Department of Health NIHR-PGfAR RP-PG-0612-20002
6 · The paper itself

Abstract

background and hypothesisCognitive remediation (CR) benefits cognition and functioning in psychosis but we do not know the optimal level of therapist contact, so we evaluated the potential benefits of different CR modes. STUDY

designA multi-arm, multi-center, single-blinded, adaptive trial of therapist-supported CR. Participants from 11 NHS early intervention psychosis services were independently randomized to Independent, Group, One-to-One, or Treatment-as-usual (TAU). The primary outcome was functional recovery (Goal Attainment Scale [GAS]) at 15-weeks post randomization. Independent and TAU arms were closed after an interim analysis, and three informative contrasts tested (Group vs One-to-One, Independent vs TAU, Group + One-to-One vs TAU). Health economic analyses considered the cost per Quality Adjusted Life Year (QALY). All analyses used intention-to-treat principles. STUDY

resultsWe analyzed 377 participants (65 Independent, 134 Group, 112 One-to-One, 66 TAU). GAS did not differ for Group vs One-to-One: Cohen's d: 0.07, -0.25 to 0.40 95% CI, P = .655; Independent vs TAU: Cohen's d: 0.07, -0.41 to 0.55 95% CI, P = .777. GAS and the cognitive score improved for Group + One-to-One vs TAU favoring CR (GAS: Cohen's d: 0.57, 0.19-0.96 95% CI, P = .003; Cognitive score: Cohens d: 0.28, 0.07-0.48 95% CI, P = .008). The QALY costs were £4306 for Group vs TAU and £3170 for One-to-One vs TAU. Adverse events did not differ between treatment methods and no serious adverse events were related to treatment.

conclusionsBoth active therapist methods provided cost-effective treatment benefiting functional recovery in early psychosis and should be adopted within services. Some individuals benefited more than others so needs further investigation.

trial registrationISRCTN14678860 https://doi.org/10.1186/ISRCTN14678860Now closed.

Indexed as

Cognitive RemediationPsychotic DisordersCognitionCost-Benefit AnalysisHealth Care CostsHumansTreatment Outcomecognitive trainingearly interventionfunctioninggoal achievementtherapist support

Identifiers

PMID36869733
PMCPMC10154711
OpenAlexW4323066422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.