Evidence map›Paper›PMID 36868964›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2023

Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder.

Eric A Fertuck, Barbara Stanley, Olena Kleshchova, J John Mann, Joy Hirsch, Kevin Ochsner, Paul Pilkonis, Jeff Erbe, Jack Grinband

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Eric A FertuckDepartment of Psychology, Clinical Psychology Doctoral Program, The City College of the City University of New York, New York, New York; Department of Psychiatry, Columbia University, New York, New York; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York. Electronic address: efertuck@ccny.cuny.edu.
Barbara StanleyDepartment of Psychiatry, Columbia University, New York, New York; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York.
Olena KleshchovaDepartment of Psychology, University of Nevada Reno, Reno, Nevada.
J John MannDepartment of Psychiatry, Columbia University, New York, New York; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York.
Joy HirschDepartments of Psychiatry, Neuroscience and Comparative Medicine, Yale School of Medicine, New Haven, Connecticut.
Kevin OchsnerDepartment of Psychology, Columbia University, New York, New York.
Paul PilkonisDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jeff ErbeDepartment of Psychology, Clinical Psychology Doctoral Program, The City College of the City University of New York, New York, New York; Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York.
Jack GrinbandDepartment of Psychiatry, Columbia University, New York, New York.
City College of New York · USColumbia University · USNew York Psychoanalytic Society and Institute · USUniversity of Nevada, Reno · USUniversity of Pittsburgh · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Social Neuroscience of Borderline Personality DisorderK23MH077044 · NIMH · RESEARCH FOUNDATION FOR MENTAL HYGIENE · PI FERTUCK, ERIC A · 2008 to 2012
$926k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K23 MH077044NIMH NIH HHS L30 MH072176
6 · The paper itself

Abstract

backgroundBorderline personality disorder (BPD) is characterized by an elevated distress response to social exclusion (i.e., rejection distress), the neural mechanisms of which remain unclear. Functional magnetic resonance imaging studies of social exclusion have relied on the classic version of the Cyberball task, which is not optimized for functional magnetic resonance imaging. Our goal was to clarify the neural substrates of rejection distress in BPD using a modified version of Cyberball, which allowed us to dissociate the neural response to exclusion events from its modulation by exclusionary context.

methodsTwenty-three women with BPD and 22 healthy control participants completed a novel functional magnetic resonance imaging modification of Cyberball with 5 runs of varying exclusion probability and rated their rejection distress after each run. We tested group differences in the whole-brain response to exclusion events and in the parametric modulation of that response by rejection distress using mass univariate analysis.

resultsAlthough rejection distress was higher in participants with BPD (F

conclusionsHeightened rejection distress in BPD might stem from a failure to maintain or upregulate the activity of the rostromedial prefrontal cortex, a key node of the mentalization network. Inverse coupling between rejection distress and mentalization-related brain activity might contribute to heightened rejection expectation in BPD.

Indexed as

Borderline Personality DisorderBrainBrain MappingFemaleHumansMagnetic Resonance ImagingPrefrontal CortexBorderline personality disorderCyberballfMRIMedial prefrontal cortexRejection distressSocial exclusion

Identifiers

PMID36868964
PMCPMC10388534
OpenAlexW4311515388

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.