Evidence map›Paper›PMID 36868851›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Human Tau Aggregates Are Permissive to Protein Synthesis-Dependent Memory in

Ergina Vourkou, Eva D Rouiz Ortega, Sumeet Mahajan, Amrit Mudher, Efthimios M C Skoulakis

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ergina VourkouInstitute for Fundamental Biomedical Research, Biomedical Sciences Research Centre Alexander Fleming, 16672 Vari, Greece.
Eva D Rouiz OrtegaSchool of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom.
Sumeet MahajanSchool of Chemistry, Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom.
Amrit MudherSchool of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom.
Efthimios M C SkoulakisInstitute for Fundamental Biomedical Research, Biomedical Sciences Research Centre Alexander Fleming, 16672 Vari, Greece skoulakis@fleming.gr.ORCID 0000-0001-5113-6192
University of Southampton · GBAlexander Fleming Biomedical Sciences Research Center · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tauopathies including Alzheimer's disease, are characterized by progressive cognitive decline, neurodegeneration, and intraneuronal aggregates comprised largely of the axonal protein Tau. It has been unclear whether cognitive deficits are a consequence of aggregate accumulation thought to compromise neuronal health and eventually lead to neurodegeneration. We use the

Indexed as

DrosophilaTauopathiesAnimalsAnimals, Genetically ModifiedDisease Models, AnimalHumansMemory DisordersMethylene Bluetau ProteinsMethylene Bluetau ProteinsDrosophilamemorymethylene bluetautau aggregationtauopathies

Identifiers

PMID36868851
PMCPMC10124960
OpenAlexW4323067275

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.