Evidence map›Paper›PMID 36868509›Full record

ArticleBrain research2023

Immunohistochemical localization of glucocorticoid receptors in the human cochlea.

Hirooki Matsui, Ivan A Lopez, Gail Ishiyama, Akira Ishiyama

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07134075 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Safety and Efficacy of Intracochlear Injection of Glucocorticoid Through the Round Window Membrane in Patients With Total Sudden Sensorineural Hearing Loss

TypeinterventionalSponsorEye & ENT Hospital of Fudan UniversityRan2025 to 2027Enrolled150ConditionsSudden Sensorineural Hearing Loss (SSNHL)Armsintracochlear triamcinolone acetonide injection, intracochlear injection of dexamethasone through the round window membrane, intracochlear dexamethasone injection and intratympanic dexamethasone injection, intratympanic dexamethasone injection
NCT07540728 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy and Safety of Trans-Round Window Membrane Intracochlear Steroid Delivery in Patients With Complete Sudden Sensorineural Hearing Loss

TypeinterventionalSponsorEye & ENT Hospital of Fudan UniversityRan2026 to 2028Enrolled108ConditionsSudden Hearing LossArmsExperimental: Group A: intracochlear triamcinolone acetonide injection, intracochlear injection of dexamethasone, intratympanic dexamethasone injection
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Hirooki MatsuiDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, USA; Department of Otolaryngology, Head and Neck Surgery, Yamagata University School of Medicine, Yamagata, Japan.
Ivan A LopezDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, USA. Electronic address: ilopez@ucla.edu.
Gail IshiyamaDepartment of Neurology. David Geffen School of Medicine at UCLA, University of California, Los Angeles, USA.
Akira IshiyamaDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, USA.
University of California, Los Angeles · USYamagata University · JP

Funding

The Human Temporal Bone Laboratory Resource for Basic and Applied Inner Ear SciencesU24DC015910 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ISHIYAMA, AKIRA · 2017 to 2022
$4.2M
Modern Cellular and Molecular Techniques to Study the Human Temporal BoneU24DC020855 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Akira Ishiyama · 2023 to 2026
$2.7M
NIDCD NIH HHS U24 DC015910NIDCD NIH HHS U24 DC020855
6 · The paper itself

Abstract

In the present study we investigated the localization of glucocorticoid receptors (GCR) in the human inner ear using immunohistochemistry. Celloidin-embedded cochlear sections of patients with normal hearing (n = 5), patients diagnosed with MD (n = 5), and noise induced hearing loss (n = 5) were immunostained using GCR rabbit affinity-purified polyclonal antibodies and secondary fluorescent or HRP labeled antibodies. Digital fluorescent images were acquired using a light sheet laser confocal microscope. In celloidin-embedded sections GCR-IF was present in the cell nuclei of hair cells and supporting cells of the organ of Corti. GCR-IF was detected in cell nuclei of the Reisner's membrane. GCR-IF was seen in cell nuclei of the stria vascularis and the spiral ligament. GCR-IF was found in the spiral ganglia cell nuclei, however, spiral ganglia neurons showed no GCR-IF. Although GCRs were found in most cell nuclei of the cochlea, the intensity of IF was differential among the different cell types being more intense in supporting cells than in sensory hair cells. The differential expression of GCR receptors found in the human cochlea may help to understand the site of action of glucocorticoids in different ear diseases.

Indexed as

Ear, InnerReceptors, GlucocorticoidAnimalsCochleaCollodionHumansRabbitsSpiral GanglionCollodionReceptors, GlucocorticoidCelloidin-embedded sectionsCochleaGlucocorticoid receptorsHuman inner ear

Identifiers

PMID36868509
PMCPMC10521330
OpenAlexW4322754290

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.