Evidence map›Paper›PMID 36868411›Full record

ArticleUrology2023

Utilizing a Questionnaire to Implement a Risk-based Antibiotic Prophylaxis Protocol for Transrectal Prostate Biopsy.

Zeynep G Gul, Michelle Yu, Danielle R Sharbaugh, Kelly R Pekala, Jonathan Y Lin, Adam J Sharbaugh, Toby S Zhu, Hermoon Worku, Kody M Armann, Chandler N Hudson and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Zeynep G GulDepartment of Urology, University of Pittsburgh, Pittsburgh, PA.
Michelle YuDepartment of Urology, University of Pittsburgh, Pittsburgh, PA.
Danielle R SharbaughDepartment of Urology, University of Pittsburgh, Pittsburgh, PA.
Kelly R PekalaDepartment of Urology, University of Pittsburgh, Pittsburgh, PA.
Jonathan Y LinDepartment of Urology, University of Pittsburgh, Pittsburgh, PA.
Adam J SharbaughDepartment of Urology, University of Pittsburgh, Pittsburgh, PA.
Toby S ZhuSchool of Medicine, University of Pittsburgh, Pittsburgh, PA.
Hermoon WorkuSchool of Medicine, University of Pittsburgh, Pittsburgh, PA.
Kody M ArmannSchool of Medicine, University of Pittsburgh, Pittsburgh, PA.
Chandler N HudsonSchool of Medicine, University of Pittsburgh, Pittsburgh, PA.
Jordan M HaySchool of Medicine, University of Pittsburgh, Pittsburgh, PA.
Valentina GrajalesDepartment of Urology, University of Pittsburgh, Pittsburgh, PA.
Jonathan G YabesDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA.
Benjamin J DaviesDepartment of Urology, University of Pittsburgh, Pittsburgh, PA.
Bruce L JacobsDepartment of Urology, University of Pittsburgh, Pittsburgh, PA. Electronic address: jacobsbl2@upmc.edu.
University of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
NCI NIH HHS P30 CA047904
6 · The paper itself

Abstract

objectiveTo develop and evaluate a risk-based antibiotic prophylaxis protocol for patients undergoing transrectal prostate biopsy.

methodsWe created a risk-based protocol for antibiotic prophylaxis before transrectal prostate biopsy. Patients were screened for infection risk-factors with a self-administered questionnaire. The protocol was implemented from January 1, 2020 to March 31, 2020. We compared patient risk-factors, antibiotic regimens, and 30-day infection rates for patients undergoing transrectal prostate biopsies during the intervention and for a 3-month period before the intervention.

resultsThere were 116 prostate biopsies in the preintervention group and 104 in the intervention group. Although there was no significant difference in the number of high-risk patients between the 2 groups (48% vs 55%; P = .33), the percentage of patients treated with augmented prophylaxis decreased from 74% to 45% (P = 0.03). The duration of antibiotic administration and the median number of doses prescribed also decreased significantly. Despite significant decreases in antibiotic use, there were no differences in infection rates (5% vs 5%; P = .90) or sepsis rates (1% vs 2%; P = .60).

conclusionWe developed a risk-based protocol for prophylactic antibiotics before prostate biopsy. The protocol was associated with less antibiotic use but did not lead to an increase in infectious complications.

Indexed as

Anti-Bacterial AgentsProstateAntibiotic ProphylaxisBiopsyHumansImage-Guided BiopsyMaleRectumAnti-Bacterial Agents

Identifiers

PMID36868411
PMCPMC11231993
OpenAlexW4322754546

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.