Evidence map›Paper›PMID 36867773›Full record

ReviewThe British journal of radiology2023

Prediction of pathological response after neoadjuvant chemotherapy using baseline FDG PET heterogeneity features in breast cancer.

Carla Oliveira, Francisco Oliveira, Sofia C Vaz, Hugo Pinto Marques, Fátima Cardoso

Open access · hybridAbstract readReview
In one paragraph

Review in The British journal of radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Predictive score for response to neoadjuvant chemotherapy in early-stage HR + /HER2- breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Baseline [European journal of nuclear medicine and molecular imaging · 2024
    Article
  6. Peritumoral Adipose Tissue Features Derived from [Journal of personalized medicine · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Comparison of MRI vs. [Journal of clinical medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Carla OliveiraNuclear Medicine-Radiopharmacology, Champalimaud Clinical Center/Champalimaud Foundation, Lisbon, Portugal.ORCID 0000-0002-2139-0904
Francisco OliveiraNuclear Medicine-Radiopharmacology, Champalimaud Clinical Center/Champalimaud Foundation, Lisbon, Portugal.
Sofia C VazNuclear Medicine-Radiopharmacology, Champalimaud Clinical Center/Champalimaud Foundation, Lisbon, Portugal.
Hugo Pinto MarquesNOVA Medical School, Lisbon, Portugal.
Fátima CardosoBreast Unit, Champalimaud Clinical Center/Champalimaud Foundation, Lisbon, Portugal.
Champalimaud Foundation · PTUniversidade Nova de Lisboa · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complete pathological response to neoadjuvant systemic treatment (NAST) in some subtypes of breast cancer (BC) has been used as a surrogate of long-term outcome. The possibility of predicting BC pathological response to NAST based on the baseline 18F-Fluorodeoxyglucose positron emission tomography (FDG PET), without the need of an interim study, is a focus of recent discussion. This review summarises the characteristics and results of the available studies regarding the potential impact of heterogeneity features of the primary tumour burden on baseline FDG PET in predicting pathological response to NAST in BC patients. Literature search was conducted on PubMed database and relevant data from each selected study were collected. A total of 13 studies were eligible for inclusion, all of them published over the last 5 years. Eight out of 13 analysed studies indicated an association between FDG PET-based tumour uptake heterogeneity features and prediction of response to NAST. When features associated with predicting response to NAST were derived, these varied between studies. Therefore, definitive reproducible findings across series were difficult to establish. This lack of consensus may reflect the heterogeneity and low number of included series. The clinical relevance of this topic justifies further investigation about the predictive role of baseline FDG PET.

Indexed as

Breast NeoplasmsFemaleFluorodeoxyglucose F18HumansNeoadjuvant TherapyPositron-Emission TomographyRadiopharmaceuticalsTreatment OutcomeFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID36867773
PMCPMC10230392
OpenAlexW4323036696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.