ArticleScience advances2023
Flaw-insensitive fatigue resistance of chemically fixed collagenous soft tissues.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 50 citations in OpenAlex.
- Self-encapsulated nanofibrous ionic skin with superhigh fatigue resistance and broad environmental tolerance.Nature communications · 2026Article
- Compliance for Resistance: The Intrinsic Extraordinary Isotropic Anti-Fatigue Performance of Fish Bladder.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Architecting bioinspired nanocrystalline domains for ultimate robust and transparent cellulose photonic hydrogels.Science advances · 2026Article
- Microscopic measurement of the local deformation field establishes the mechanistic origin of the fatigue threshold for soft brittle materials.Soft matter · 2026Article
- Structural Motifs in Soft Fibrous Tissues: Revealing Structure-Mechanics Relationships in Deformation and Tear Resistance for Biomimetic Material Design.Advanced healthcare materials · 2025Review
- Flaw Sensitivity of Tough and Self-Healing Hydrogels with Hierarchical Structure.Polymer science & technology (Washington, D.C.) · 2025Article
- Why are soft collagenous tissues so tough?Science advances · 2025Article
- Article
- Innovation and Development in Polymer Heart Valves: A New Era of Transcatheter Aortic Valve Replacement.European cardiology · 2025Review
- Anisotropic Liesegang pattern for the nonlinear elastic biomineral-hydrogel complex.Science advances · 2024Article
- Self-compliant ionic skin by leveraging hierarchical hydrogen bond association.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bovine pericardium (BP) has been used as leaflets of prosthetic heart valves. The leaflets are sutured on metallic stents and can survive 400 million flaps (~10-year life span), unaffected by the suture holes. This flaw-insensitive fatigue resistance is unmatched by synthetic leaflets. We show that the endurance strength of BP under cyclic stretch is insensitive to cuts as long as 1 centimeter, about two orders of magnitude longer than that of a thermoplastic polyurethane (TPU). The flaw-insensitive fatigue resistance of BP results from the high strength of collagen fibers and soft matrix between them. When BP is stretched, the soft matrix enables a collagen fiber to transmit tension over a long length. The energy in the long length dissipates when the fiber breaks. We demonstrate that a BP leaflet greatly outperforms a TPU leaflet. It is hoped that these findings will aid the development of soft materials for flaw-insensitive fatigue resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.