Evidence map›Paper›PMID 36867441›Full record

ArticleJournal of applied clinical medical physics2023

TrDosePred: A deep learning dose prediction algorithm based on transformers for head and neck cancer radiotherapy.

Chenchen Hu, Haiyun Wang, Wenyi Zhang, Yaoqin Xie, Ling Jiao, Songye Cui

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  8. High-dose-rate Brachytherapy Planning with Dendrite Cross-Attention UNet.Proceedings of SPIE--the International Society for Optical Engineering · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenchen HuInstitute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Haiyun WangInstitute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Wenyi ZhangInstitute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Yaoqin XieShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Ling JiaoInstitute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Songye CuiShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundIntensity-Modulated Radiation Therapy (IMRT) has been the standard of care for many types of tumors. However, treatment planning for IMRT is a time-consuming and labor-intensive process. PURPOSE: To alleviate this tedious planning process, a novel deep learning based dose prediction algorithm (TrDosePred) was developed for head and neck cancers.

methodsThe proposed TrDosePred, which generated the dose distribution from a contoured CT image, was a U-shape network constructed with a convolutional patch embedding and several local self-attention based transformers. Data augmentation and ensemble approach were used for further improvement. It was trained based on the dataset from Open Knowledge-Based Planning Challenge (OpenKBP). The performance of TrDosePred was evaluated with two mean absolute error (MAE) based scores utilized by OpenKBP challenge (i.e., Dose score and DVH score) and compared to the top three approaches of the challenge. In addition, several state-of-the-art methods were implemented and compared to TrDosePred.

resultsThe TrDosePred ensemble achieved the dose score of 2.426 Gy and the DVH score of 1.592 Gy on the test dataset, ranking at 3rd and 9th respectively in the leaderboard on CodaLab as of writing. In terms of DVH metrics, on average, the relative MAE against the clinical plans was 2.25% for targets and 2.17% for organs at risk.

conclusionsA transformer-based framework TrDosePred was developed for dose prediction. The results showed a comparable or superior performance as compared to the previous state-of-the-art approaches, demonstrating the potential of transformer to boost the treatment planning procedures.

Indexed as

Deep LearningHead and Neck NeoplasmsRadiotherapy, Intensity-ModulatedAlgorithmsHumansOrgans at RiskRadiotherapy DosageRadiotherapy Planning, Computer-Assisteddeep learningradiation therapytreatment planning

Identifiers

PMID36867441
PMCPMC10338766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.