Evidence map›Paper›PMID 36867349›Full record

ArticleTranslational stroke research2024

A Novel Rat Model of Embolic Cerebral Ischemia Using a Cell-Implantable Radiopaque Hydrogel Microfiber.

Teppei Komatsu, Hiroki Ohta, Naoki Takakura, Junichi Hata, Tomomichi Kitagawa, Yuta Kurashina, Hiroaki Onoe, Hirotaka James Okano, Yasuyuki Iguchi

Abstract read
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In one paragraph

Article in Translational stroke research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Teppei Komatsu *Department of Neurology, the Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo, Japan, 105-8461. teppeinoieni.coicoi@jikei.ac.jp.
Hiroki Ohta *Division of Regenerative Medicine, Research Center for Medical Sciences, the Jikei University School of Medicine, Tokyo, Japan.
Naoki Takakura *School of integrated DESIGN Engineering, Faculty of Science and Technology, Keio University, Kanagawa, Japan.
Junichi HataDepartment of Radiological Science, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Tomomichi KitagawaDepartment of Neurology, the Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo, Japan, 105-8461.
Yuta KurashinaDepartment of Mechanical Engineering, Faculty of Science and Technology, Keio University, Kanagawa, Japan.
Hiroaki OnoeDepartment of Mechanical Engineering, Faculty of Science and Technology, Keio University, Kanagawa, Japan.
Hirotaka James OkanoDivision of Regenerative Medicine, Research Center for Medical Sciences, the Jikei University School of Medicine, Tokyo, Japan.
Yasuyuki IguchiDepartment of Neurology, the Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo, Japan, 105-8461.
Jikei University School of Medicine · JPKeio University · JPTokyo Metropolitan University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The failure of neuroprotective treatment-related clinical trials, including stem cell therapies, may be partially due to a lack of suitable animal models. We have developed a stem cell-implantable radiopaque hydrogel microfiber that can survive for a long time in vivo. The microfiber is made of barium alginate hydrogel containing zirconium dioxide, fabricated in a dual coaxial laminar flow microfluidic device. We aimed to develop a novel focal stroke model using this microfiber. Using male Sprague-Dawley rats (n=14), a catheter (inner diameter, 0.42 mm; outer diameter, 0.55 mm) was navigated from the caudal ventral artery to the left internal carotid artery using digital subtraction angiography. A radiopaque hydrogel microfiber (diameter, 0.4 mm; length, 1 mm) was advanced through the catheter by slow injection of heparinized physiological saline to establish local occlusion. Both 9.4-T magnetic resonance imaging at 3 and 6 h and 2% 2,3,5-triphenyl tetrazolium chloride staining at 24 h after stroke model creation were performed. Neurological deficit score and body temperature were measured. The anterior cerebral artery-middle cerebral artery bifurcation was selectively embolized in all rats. Median operating time was 4 min (interquartile range [IQR], 3-8 min). Mean infarct volume was 388 mm

Indexed as

Disease Models, AnimalRats, Sprague-DawleyAnimalsBrain IschemiaHydrogelsMagnetic Resonance ImagingMaleRatsHydrogelsAnimal modelIschemic strokeMiddle cerebral artery occlusionRatRegenerationStem cell

Identifiers

PMID36867349
OpenAlexW4323036285

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.