ArticleEuropean journal of nuclear medicine and molecular imaging2023
Regional brain glucose metabolism is differentially affected by ketogenic diet: a human semiquantitative positron emission tomography.
Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 4 citations in OpenAlex.
- Anti-Inflammatory and Antioxidant Strategies in Epilepsy: From Molecular Mechanisms to Threshold Management.International journal of molecular sciences · 2026Review
- Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma.BMC medicine · 2024Review
- Persistent brain metabolic impairment in long COVID patients with persistent clinical symptoms: a nine-month follow-up [European journal of nuclear medicine and molecular imaging · 2024Article
- Current status and perspectives of nuclear cardiology.Annals of nuclear medicine · 2024Review
- Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations.Biomedicines · 2023Review
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6 authors at 2 institutions in 1 country.
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Abstract
purposeKetogenic diet (KD) is recommended to avoid intense [
methodSubjects who underwent KD prior to whole-body and brain [
resultsA 20% lower brain SUVmax was found in subjects under KD with MGS in comparison to those without MGS (Student's t-test, p = 0.02). Whole-brain voxel-based intergroup analysis revealed that patients under KD with and without MGS had relative hypermetabolism of limbic regions including medial temporal cortices and cerebellum lobes and relative hypometabolism of bilateral posterior regions (occipital), without significant difference between them.
conclusionKD globally reduces brain glucose metabolism but with regional differences, requiring special attention to clinical interpretation. On a pathophysiological perspective, these findings could help understand underlying neurological effects of KD through possible decrease of oxidative stress in posterior regions and functional compensation in the limbic regions.
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