ArticleInvestigative ophthalmology & visual science2023
Causal Relationships Between Glycemic Traits and Myopia.
Article in Investigative ophthalmology & visual science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Pooled it
- The relationship between refractive error and the risk of diabetic retinopathy: a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Myopia Prevalence Among 6-17 Years Students in Rural Areas of Seven Provinces of China.Journal of clinical medicine · 2026Article
- Mendelian Randomization Studies of Myopia: Choosing the Right Summary Statistics.Investigative ophthalmology & visual science · 2025Article
- IMI-Myopia Genetics Report.Investigative ophthalmology & visual science · 2025Review
- Causal relationships between depression, anxiety, and myopia: a two-sample Mendelian randomization study.Eye (London, England) · 2025Article
- Association Between Omega-3 Polyunsaturated Fatty Acids and Myopia: Results From the Two-Sample and Multi-Tissue Genomic Mendelian Randomization Study and KNHANES.Food science & nutrition · 2025Article
- Preliminary insights into serum metabolomics in atrophic myopic maculopathy: potential link to fatty acid metabolism dysregulation.BMC ophthalmology · 2025Article
- Causal effects of allergic diseases on the risk of myopia: a two-sample Mendelian randomization study.Eye (London, England) · 2025Article
- Myopia development: multifactorial interplay, molecular mechanisms and possible strategies.Frontiers in medicine · 2025Review
- Risk of inappropriate causal inference in Mendelian randomization studies on myopia.Eye (London, England) · 2024Article
- Genome-Wide Association Analysis Identifies LILRB2 Gene for Pathological Myopia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Correlation analysis of myopia and dietary factors among primary and secondary school students in Shenyang, China.Scientific reports · 2024Article
- Application of mendelian randomization in ocular diseases: a review.Human genomics · 2024Review
- Glutathione and a Pool of Metabolites Partly Related to Oxidative Stress Are Associated with Low and High Myopia in an Altered Bioenergetic Environment.Antioxidants (Basel, Switzerland) · 2024Article
- Potential causal associations between leisure sedentary behaviors, physical activity, sleep traits, and myopia: a Mendelian randomization study.BMC ophthalmology · 2024Article
- Treatment of Rapid Progression of Myopia: Topical Atropine 0.05% and MF60 Contact Lenses.Vision (Basel, Switzerland) · 2024Article
- Genetic correlation and causal relationship between sleep and myopia: a mendelian randomization study.Frontiers in genetics · 2024Article
- A review of mechanism of action of outdoor exposure in preventing myopia incidence and progression.International journal of ophthalmology · 2024Review
- Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study.Frontiers in microbiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Little is known about whether sugar intake is a risk factor for myopia, and the influence of glycemic control remains unclear, with inconsistent results reported. This study aimed to clarify this uncertainty by evaluating the link between multiple glycemic traits and myopia. Methods: We employed a two-sample Mendelian randomization (MR) design using summary statistics from independent genome-wide association studies. A total of six glycemic traits, including adiponectin, body mass index, fasting blood glucose, fasting insulin, hemoglobin A1c (HbA1c), and proinsulin levels, were used as exposures, and myopia was used as the outcome. The inverse-variance-weighted (IVW) method was the main applied analytic tool and was complemented with comprehensive sensitivity analyses. Results: Out of the six glycemic traits studied, we found that adiponectin was significantly associated with myopia. The genetically predicted level of adiponectin was consistently negatively associated with myopia incidence: IVW (odds ratio [OR] = 0.990; P = 2.66 × 10-3), MR Egger (OR = 0.983; P = 3.47 × 10-3), weighted median method (OR = 0.989; P = 0.01), and weighted mode method (OR = 0.987; P = 0.01). Evidence from all sensitivity analyses further supported these associations. In addition, a higher HbA1c level was associated with a greater risk of myopia: IVW (OR = 1.022; P = 3.06 × 10-5). Conclusions: Genetic evidence shows that low adiponectin levels and high HbA1c are associated with an increased risk of myopia. Given that physical activity and sugar intake are controllable variables in blood glycemia treatment, these findings provide new insights into potential strategies to delay myopia onset.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.