ArticleeLife2023
Molecular and spatial profiling of the paraventricular nucleus of the thalamus.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 40 citations in OpenAlex.
- Paratenial thalamus engages in reciprocal and broadcast circuits with the prefrontal cortex.Cell reports · 2026Article
- Article
- PVT inhibition mitigates neuropathology and cognitive deficits in chronic cerebral hypoperfusion.iScience · 2026Article
- Bypassing the VTA: Thalamic modulation of striatal dopamine prioritizes safety.Nature communications · 2026Article
- A synaptic mechanism for encoding the learned value of action-derived safety.Nature communications · 2026Article
- Excitatory paraventricular thalamus-posterior insular cortex circuit mediates pain-anxiety comorbidity in diabetic neuropathy.Translational psychiatry · 2026Article
- Peptide signaling in the paraventricular thalamus contributes to disrupted adult reward behaviors after early-life adversity.bioRxiv : the preprint server for biology · 2026Article
- Corticotropin releasing hormone-expressing inputs to the thalamic paraventricular nucleus: pathways from mother to memory?Neurobiology of stress · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- The encoding of interoceptive-based predictions by the paraventricular nucleus of the thalamus D2R+ neurons.iScience · 2026Article
- Disturbances of paraventricular thalamic nucleus neurons in bipolar disorder revealed by single-nucleus analysis.Nature communications · 2026Article
- Paraventricular thalamic neurons respond to vagus nerve activation and modulate anxious behavior.Frontiers in neural circuits · 2026Article
- Convergence and Segregation of Excitatory and Inhibitory Afferents in the Paraventricular Thalamic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A Combined Neuroanatomy, Ex Vivo Imaging, and Immunohistochemistry Defined MRI Mask for the Human Paraventricular Nucleus of the Thalamus.Human brain mapping · 2025Article
- Article
- Uncovering the role of Gpr45 in obesity regulation.Molecular metabolism · 2025Article
- A stress-sensing circuit signals to the central pacemaker to reprogram circadian rhythms.Science advances · 2025Article
- Genotype-dependent functional role of the anterior and posterior paraventricular thalamus in pavlovian conditioned approach.Psychopharmacology · 2025Article
- A combined neuroanatomy, ex vivo imaging and immunohistochemistry defined MRI mask for the human paraventricular nucleus of the thalamus.bioRxiv : the preprint server for biology · 2025Article
- Pituitary adenylate cyclase-activating polypeptide (PACAP)Psychopharmacology · 2025Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The paraventricular nucleus of the thalamus (PVT) is known to regulate various cognitive and behavioral processes. However, while functional diversity among PVT circuits has often been linked to cellular differences, the molecular identity and spatial distribution of PVT cell types remain unclear. To address this gap, here we used single nucleus RNA sequencing (snRNA-seq) and identified five molecularly distinct PVT neuronal subtypes in the mouse brain. Additionally, multiplex fluorescent in situ hybridization of top marker genes revealed that PVT subtypes are organized by a combination of previously unidentified molecular gradients. Lastly, comparing our dataset with a recently published single-cell sequencing atlas of the thalamus yielded novel insight into the PVT's connectivity with the cortex, including unexpected innervation of auditory and visual areas. This comparison also revealed that our data contains a largely non-overlapping transcriptomic map of multiple midline thalamic nuclei. Collectively, our findings uncover previously unknown features of the molecular diversity and anatomical organization of the PVT and provide a valuable resource for future investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.