Evidence map›Paper›PMID 36866666›Full record

ArticleCirculation. Genomic and precision medicine2023

Validation of a Polygenic Score for Beta-Blocker Survival Benefit in Patients With Heart Failure Using the United Kingdom Biobank.

David E Lanfear, Jasmine A Luzum, Ruicong She, Jia Li, Hani N Sabbah, Nicole Zeld, Bin Liu, Edward Peterson, L Keoki Williams

Abstract readLetter
In one paragraph

Article in Circulation. Genomic and precision medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Review
  6. Using Omics to Identify Novel Therapeutic Targets in Heart Failure.Circulation. Genomic and precision medicine · 2024
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David E LanfearCenter for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Hospital, Detroit, MI (D.E.L., J.A.L., N.Z., L.K.W.).ORCID 0000-0001-6471-1483
Jasmine A LuzumCenter for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Hospital, Detroit, MI (D.E.L., J.A.L., N.Z., L.K.W.).ORCID 0000-0003-3639-717X
Ruicong SheDepartment of Public Health Sciences (R.S., J.L., B.L., E.P.), Henry Ford Health System, Detroit, MI.
Jia LiDepartment of Public Health Sciences (R.S., J.L., B.L., E.P.), Henry Ford Health System, Detroit, MI.ORCID 0000-0002-5931-3058
Hani N SabbahHeart and Vascular Institute (D.E.L., H.N.S.), Henry Ford Health System, Detroit, MI.ORCID 0000-0002-2850-6105
Nicole ZeldCenter for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Hospital, Detroit, MI (D.E.L., J.A.L., N.Z., L.K.W.).ORCID 0000-0001-9096-8071
Bin LiuDepartment of Public Health Sciences (R.S., J.L., B.L., E.P.), Henry Ford Health System, Detroit, MI.ORCID 0000-0002-3280-9336
Edward PetersonDepartment of Public Health Sciences (R.S., J.L., B.L., E.P.), Henry Ford Health System, Detroit, MI.
L Keoki WilliamsCenter for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Hospital, Detroit, MI (D.E.L., J.A.L., N.Z., L.K.W.).ORCID 0000-0002-7592-5791

Funding

ACHIEVE P3 - CHDP50MD017351 · NIMHD · WAYNE STATE UNIVERSITY · PI BROOK, ROBERT DANIEL · 2021 to 2025
$21.1M
PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMAR01AI079139 · NIAID · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2009 to 2013
$3.9M
Impact of Race and Genetic Factors on Beta-blocker Effectiveness in Heart FailureR01HL103871 · NHLBI · HENRY FORD HEALTH SYSTEM · PI LANFEAR, DAVID E · 2011 to 2015
$3.5M
Leveraging electronic medical records to perform large-scale diabetes pharmacogenomics among ancestrally diverse patient populationsR01DK113003 · NIDDK · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2017 to 2021
$3.2M
Plasma Metabolomics and Myocardial Energetics in Heart FailureR01HL132154 · NHLBI · HENRY FORD HEALTH SYSTEM · PI LANFEAR, DAVID E, SABBAH, HANI N · 2017 to 2020
$3.1M
Poly-omic Study of Asthma Exacerbations in Diverse PopulationsR01HL141845 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2019 to 2022
$3.0M
Combined Transcriptomics and Genomics to Find Asthma Genes in Admixed PopulationsR01HL118267 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2014 to 2017
$2.9M
VALIDATION OF ADHERENCE DATA--USE IN CLINICAL PRACTICER01DK064695 · NIDDK · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2003 to 2010
$2.7M
Precision Medicine for Heart Failure: The Role of Genomics in the Efficacy and Racial Disparity of Cornerstone PharmacotherapyK08HL146990 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUZUM, JASMINE A · 2019 to 2023
$772k
NHLBI NIH HHS K08 HL146990NHLBI NIH HHS L30 HL110279NHLBI NIH HHS R01 HL103871NHLBI NIH HHS R01 HL118267NHLBI NIH HHS R01 HL132154NHLBI NIH HHS R01 HL141845NIAID NIH HHS R01 AI079139NIDDK NIH HHS R01 DK064695NIDDK NIH HHS R01 DK113003NIMHD NIH HHS P50 MD017351
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biological Specimen BanksHeart FailureAdrenergic beta-AntagonistsHumansUnited KingdomAdrenergic beta-Antagonistsadrenergic beta antagonistsgenome wide association studyheart failureprecision medicinesurvival

Identifiers

PMID36866666
PMCPMC10121886

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.