Evidence map›Paper›PMID 36866634›Full record

ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2023

Canonical and non-canonical functions of STAT in germline stem cell maintenance.

Yalan Xing, Kimberly Larson, Jinghong Li, Willis X Li

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Computational simulation of JAK/STAT signaling in somatic versus germline stem cells.Developmental dynamics : an official publication of the American Association of Anatomists · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yalan XingDepartment of Medicine, University of California at San Diego, La Jolla, California, USA.
Kimberly LarsonDepartment of Medicine, University of California at San Diego, La Jolla, California, USA.
Jinghong LiDepartment of Medicine, University of California at San Diego, La Jolla, California, USA.
Willis X LiDepartment of Medicine, University of California at San Diego, La Jolla, California, USA.ORCID 0000-0001-9041-7341
University of Rochester Medical Center · USUniversity of California San Diego · US

Funding

Mechanism of heterochromatin regulation by STATR01GM131044 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LI, WILLIS X · 2018 to 2021
$1.3M
Functions of a novel suppressor of oncogenic RasR03CA277213 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LI, WILLIS X · 2023 to 2024
$158k
NCI NIH HHS R03 CA277213NIGMS NIH HHS R01 GM131044
6 · The paper itself

Abstract

backgroundMaintenance of the Drosophila male germline stem cells (GSCs) requires activation of the Janus kinase/signal transducer and activators of transcription (JAK/STAT) pathway by niche signals. The precise role of JAK/STAT signaling in GSC maintenance, however, remains incompletely understood.

resultsHere, we show that, GSC maintenance requires both canonical and non-canonical JAK/STAT signaling, in which unphosphorylated STAT (uSTAT) maintains heterochromatin stability by binding to heterochromatin protein 1 (HP1). We found that GSC-specific overexpressing STAT, or even the transcriptionally inactive mutant STAT, increases GSC number and partially rescues the GSC-loss mutant phenotype due to reduced JAK activity. Furthermore, we found that both HP1 and STAT are transcriptional targets of the canonical JAK/STAT pathway in GSCs, and that GSCs exhibit higher heterochromatin content.

conclusionsThese results suggest that persistent JAK/STAT activation by niche signals leads to the accumulation of HP1 and uSTAT in GSCs, which promote heterochromatin formation important for maintaining GSC identity. Thus, the maintenance of Drosophila GSCs requires both canonical and non-canonical STAT functions within GSCs for heterochromatin regulation.

Indexed as

Drosophila ProteinsJanus KinasesAnimalsChromobox Protein Homolog 5DrosophilaDrosophila melanogasterGerm CellsHeterochromatinSignal TransductionSTAT Transcription FactorsStem Cell NicheStem CellsChromobox Protein Homolog 5Drosophila ProteinsHeterochromatinJanus KinasesSTAT Transcription FactorsDrosophilagermline stem cellheterochromatinnon-canonical STAT

Identifiers

PMID36866634
PMCPMC10238624
OpenAlexW4321497685

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.