Total Reactive Isocyanate Group (TRIG) Measurement: A Commentary.

Exposure to airborne isocyanates has, for decades, been a leading cause of occupational asthma. As respiratory sensitizers, isocyanates can induce allergic respiratory diseases with symptoms persisting even without further exposure. As this cause of occupational asthma is recognized it should be almost entirely preventable. In several countries isocyanates are assigned occupational exposure limits based on the total of reactive isocyanate groups (TRIG). The measurement of TRIG has some significant advantages over the measurement of individual isocyanate compounds. This exposure metric is explicit, simplifying calculations, and comparisons across published data. It reduces the risk of underestimating exposure by 'missing' important isocyanate compounds that may be present but are not the target analytes. It allows for quantification of exposure to complex mixtures of isocyanates, di-isocyanates monomers, prepolymers, polyisocyanates, oligomers, and/or intermediate forms. This is becoming increasingly important as more complex isocyanate products are being used in the workplace. There are many methods and techniques for measuring air concentrations/potential exposure to isocyanates. Several established methods have been standardized and published as International Organization for Standardization (ISO) methods. While some may be applied directly for determination of TRIG, others (developed for determination of individual isocyanates), require modification. This commentary aims to highlight the relative merits and limitations of those methods capable of determining TRIG and also considers potential future developments.