Evidence map›Paper›PMID 36866357›Full record

ReviewFrontiers in molecular neuroscience2023

Modulation of neuronal excitability by binge alcohol drinking.

Pablo Gimenez-Gomez, Timmy Le, Gilles E Martin

Abstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Pre- and postsynaptic signatures in the prelimbic cortex associated with "alcohol use disorder" in the rat.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  3. Article
  4. The Stage-Based Model of Addiction-UsingInternational journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pablo Gimenez-GomezDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Timmy LeDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Gilles E MartinDepartment of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA, United States.

Funding

Effects of binge alcohol drinking on synaptic computing in the nucleus accumbensR01AA027807 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MARTIN, GILLES E · 2020 to 2024
$2.3M
EtOH Modulation of Synaptic Plasticity in Nucleus AccumbensR01AA020501 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MARTIN, GILLES E · 2012 to 2016
$1.6M
NIAAA NIH HHS R01 AA020501NIAAA NIH HHS R01 AA027807
6 · The paper itself

Abstract

Drug use poses a serious threat to health systems throughout the world. The number of consumers rises every year being alcohol the drug of abuse most consumed causing 3 million deaths (5.3% of all deaths) worldwide and 132.6 million disability-adjusted life years. In this review, we present an up-to-date summary about what is known regarding the global impact of binge alcohol drinking on brains and how it affects the development of cognitive functions, as well as the various preclinical models used to probe its effects on the neurobiology of the brain. This will be followed by a detailed report on the state of our current knowledge of the molecular and cellular mechanisms underlying the effects of binge drinking on neuronal excitability and synaptic plasticity, with an emphasis on brain regions of the meso-cortico limbic neurocircuitry.

Indexed as

alcoholbinge alcohol drinkingion channelneuroadaptationneuronal excitability

Identifiers

PMID36866357
PMCPMC9971943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.