Evidence map›Paper›PMID 36865544›Full record

ArticleFrontiers in immunology2023

CD4

Celestine N Wanjalla, Curtis L Gabriel, Hubaida Fuseini, Samuel S Bailin, Mona Mashayekhi, Joshua Simmons, Christopher M Warren, David R Glass, Jared Oakes, Rama Gangula and 11 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Mapping CMV-related immune signatures in blood, aorta and perivascular mediastinal adipose tissue.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  6. Article
  7. Mouse Models of HIV-Associated Atherosclerosis.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Review
  10. Review
  11. Alterations in CX3CL1 Levels and Its Role in Viral Pathogenesis.International journal of molecular sciences · 2024
    Review
  12. Fatty Liver Disease: Enter the Metabolic Era.Current HIV/AIDS reports · 2023
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Celestine N WanjallaDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
Curtis L GabrielDivision of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN, United States.
Hubaida FuseiniDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
Samuel S BailinDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
Mona MashayekhiDivision of Endocrinology, Vanderbilt University Medical Center, Nashville, TN, United States.
Joshua SimmonsDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
Christopher M WarrenDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
David R GlassVaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Jared OakesDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
Rama GangulaDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
Erin WilfongDivision of Rheumatology, Vanderbilt University Medical Center, Nashville, TN, United States.
Stephen PriestDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
Tecla TemuDepartment of Global Health, University of Washington, Seattle, WA, United States.
Evan W NewellVaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Suman PakalaDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
Spyros A KalamsDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
Sara GianellaDepartment of Medicine, University of California, San Diego, CA, United States.
David SmithDepartment of Medicine, University of California, San Diego, CA, United States.
David G HarrisonDivision of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, United States.
Simon A MallalDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
John R KoetheDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, United States.
Vanderbilt University Medical Center · USFred Hutch Cancer Center · USUniversity of California, San Diego · USUniversity of Washington · US

Funding

LC: HIV Vaccine Trials NetworkUM1AI068618 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Margaret Juliana McElrath · 2011 to 2026
$483.6M
HOPE - HIV Obstruction by Programmed EpigeneticsUM1AI164559 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI Lishomwa C Ndhlovu, Melanie Maria Ott · 2021 to 2026
$32.2M
Systems Biology CoreU19AI128914 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Margaret Juliana McElrath, KENNETH D STUART · 2017 to 2026
$29.5M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John Koethe · 2015 to 2026
$27.5M
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
The Role of Adipose-Resident T Cells in HIV-Associated Glucose IntoleranceR01DK112262 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KOETHE, JOHN · 2017 to 2021
$3.8M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
Anti-cytomegalovirus Immune Responses in Atherosclerotic Cardiovascular Disease in Persons Living with HIVK23HL156759 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WANJALLA, CELESTINE N · 2021 to 2025
$860k
The Gut Microbiota, Inflammation and Cardiovascular Disease in HIV-InfectedIndividuals.K01HL147723 · NHLBI · UNIVERSITY OF WASHINGTON · PI TEMU, TECLA MTUI · 2020 to 2022
$505k
NHLBI NIH HHS K01 HL147723NHLBI NIH HHS K23 HL156759NHLBI NIH HHS L30 HL165482NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007444NIAID NIH HHS P30 AI110527NIAID NIH HHS U19 AI128914NIAID NIH HHS UM1 AI068618NIAID NIH HHS UM1 AI164559NIDDK NIH HHS R01 DK112262
6 · The paper itself

Abstract

Persons with HIV (PWH) on long-term antiretroviral therapy (ART) have a higher incidence and prevalence of cardiometabolic diseases attributed, in part, to persistent inflammation despite viral suppression. In addition to traditional risk factors, immune responses to co-infections such as cytomegalovirus (CMV) may play an unappreciated role in cardiometabolic comorbidities and offer new potential therapeutic targets in a subgroup of individuals. We assessed the relationship of CX3CR1

Indexed as

Cardiovascular DiseasesCD4-Positive T-LymphocytesHIV InfectionsCalciumCX3C Chemokine Receptor 1CytomegalovirusHumansRisk FactorsT-Lymphocyte SubsetsCalciumCX3C Chemokine Receptor 1CX3CR1 protein, humancardiometabolic diseaseCD4 T cellsCGCcytomegalovirusHIV

Identifiers

PMID36865544
PMCPMC9971959
OpenAlexW4320712638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.