Evidence map›Paper›PMID 36865524›Full record

ArticleFrontiers in immunology2022

SIRT2-PFKP interaction dysregulates phagocytosis in macrophages with acute ethanol-exposure.

Anugraha Gandhirajan, Sanjoy Roychowdhury, Christopher Kibler, Emily Cross, Susamma Abraham, Annett Bellar, Laura E Nagy, Rachel Greenberg Scheraga, Vidula Vachharajani

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  8. Review
  9. The role of acetylation and deacetylation in cancer metabolism.Clinical and translational medicine · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. TRPV4 Regulates the Macrophage Metabolic Response to Limit Sepsis-induced Lung Injury.American journal of respiratory cell and molecular biology · 2024
    Article
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Anugraha GandhirajanDepartment of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.
Sanjoy RoychowdhuryDepartment of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.
Christopher KiblerDepartment of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.
Emily CrossDepartment of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.
Susamma AbrahamDepartment of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.
Annett BellarDepartment of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.
Laura E NagyDepartment of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.
Rachel Greenberg ScheragaDepartment of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.
Vidula VachharajaniDepartment of Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · US

Funding

Project Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI Thomas M McIntyre · 2016 to 2026
$19.6M
TRPV4 Regulates Mechanosensitive Macrophage Functions in Lung InjuryR01HL155064 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI SCHERAGA, RACHEL GREENBERG · 2021 to 2025
$2.1M
Immuno-metabolic dysfunction in alcohol with sepsisR01AA028763 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI VACHHARAJANI, VIDULA · 2021 to 2025
$2.0M
Spinning Disk Confocoal MicroscopeS10RR026820 · NCRR · CLEVELAND CLINIC LERNER COM-CWRU · PI DRAZBA, JUDY · 2010 to 2010
$500k
NCRR NIH HHS S10 RR026820NHLBI NIH HHS R01 HL155064NIAAA NIH HHS P50 AA024333NIAAA NIH HHS R01 AA028763
6 · The paper itself

Abstract

Alcohol abuse, reported by 1/8

Indexed as

EthanolMacrophagesPhagocytosisPhosphofructokinase-1, Type CSirtuin 2AnimalsHumansMiceEthanolPhosphofructokinase-1, Type CSirt2 protein, mouseSirtuin 2ethanol-exposureglycolysisLC3-associated phagocytosismacrophagephagocytosissepsisSirtuin 2

Identifiers

PMID36865524
PMCPMC9972587
OpenAlexW4318200640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.