SynthesisFrontiers in aging neuroscience2023
Exercise sustains motor function in Parkinson's disease: Evidence from 109 randomized controlled trials on over 4,600 patients.
Synthesis in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05854524 (Exploring the Biological Basis for Exercise Neuroprotection in Parkinson's Disease), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploring the Biological Basis for Exercise Neuroprotection in Parkinson's Disease
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Quality assessment and umbrella review of systematic reviews about dance for people with Parkinson's disease.PloS one · 2024Pooled it
- Changes of brain-derived neurotrophic factor (BDNF) levels after different exercise protocols: a systematic review of clinical studies in Parkinson's disease.Frontiers in physiology · 2024Pooled it
- Mapping motor exercise interventions in Parkinson's disease: a scoping review of intervention types, outcomes, adherence, and dropout.Frontiers in sports and active living · 2026Review
- Evaluating climbing interventions for Parkinson's disease: a systematic review.Frontiers in sports and active living · 2026Review
- Article
- Comparison of the Impact of Various Exercise Modalities on Parkinson's Disease.Journal of movement disorders · 2025Article
- Aquatic Therapy Versus Land-Based Therapy in Patients with Parkinson's Disease: A Systematic Review.Journal of functional morphology and kinesiology · 2025Review
- Physical Activities and Parkinson's Disease Progression: A Two-Sample Mendelian Randomization Study.CNS neuroscience & therapeutics · 2025Article
- Gait ecological assessment in persons with Parkinson's disease engaged in a synchronized musical rehabilitation program.NPJ Parkinson's disease · 2025Article
- Article
- Exercise Habits in People with Parkinson's: A Multinational Survey.Movement disorders clinical practice · 2024Article
- Advice to People with Parkinson's in My Clinic: Exercise.Journal of Parkinson's disease · 2024Article
- Online training program maintains motor functions and quality of life in patients with Parkinson's disease.Frontiers in digital health · 2024Article
- Effects of Physical Exercise on Cerebral Blood Velocity in Older Adults: A Systematic Review and Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2023Review
- Unleashing the potential of dance: a neuroplasticity-based approach bridging from older adults to Parkinson's disease patients.Frontiers in aging neuroscience · 2023Review
- Digital monitoring of motor function in Parkinson's disease using Markerless motion analysis and exergaming.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical exercise has been widely identified as a supplementary therapy for Parkinson's disease (PD). Evaluating changes in motor function over long-term periods of exercise and comparing efficacy of various exercise types will enable a better understanding of the effects of exercise on PD. In the current study, a total of 109 studies that covered 14 types of exercise were included in the analyses, enrolling 4,631 PD patients. The results of meta-regression revealed that chronic exercise delays the progression of PD motor symptoms, mobility, and balance decline deterioration, whereas for the non-exercise PD groups, motor function progressively decline. Results from network meta-analyses suggest that dancing is the optimal exercise for general motor symptoms of PD. Furthermore, Nordic walking is the most efficient exercise to mobility and balance performance. The results from network meta-analyses also suggest that Qigong may have specific benefit in improving hand function. The findings of the current study provide further evidence that chronic exercise preserves the progression of motor function decline in PD and suggest that dancing, yoga, multimodal training, Nordic walking, aquatic training, exercise gaming, and Qigong are effective PD exercises. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=276264, identifier: CRD42021276264.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.