Evidence map›Paper›PMID 36865395›Full record

ArticlePreventive medicine reports2023

Clinician barriers, perceptions, and practices in treating patients with hepatitis C virus and substance use disorder in the United States.

Haesuk Park, Carolyn Brown, Debbie L Wilson, Pei-Lin Huang, Pilar Hernández-Con, Patrick Horne, Amie Goodin, Amanda Joseph, Rich Segal, Roniel Cabrera and 1 more

Open access · goldAbstract read
In one paragraph

Article in Preventive medicine reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Clinical and demographic characteristics of participants in a hepatitis C treatment trial in rural Kentucky: How policies around treatment access may impact elimination efforts in the United States.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2026
    Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Haesuk ParkPharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Carolyn BrownHealth Outcomes, College of Pharmacy, University of Texas, Austin, TX, United States.
Debbie L WilsonPharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Pei-Lin HuangPharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Pilar Hernández-ConPharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Patrick HornePharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Amie GoodinPharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Amanda JosephPharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Rich SegalPharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, United States.
Roniel CabreraDepartment of Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Robert L CookDepartment of Epidemiology, College of Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, United States.
University of Florida · US

Funding

Medicaid Prior Authorization Policies for Chronic Hepatitis C Treatment in Vulnerable PopulationsK01DA045618 · NIDA · UNIVERSITY OF FLORIDA · PI PARK, HAESUK · 2018 to 2022
$648k
NIDA NIH HHS K01 DA045618
6 · The paper itself

Abstract

The likelihood of clinicians prescribing direct-acting antiviral (DAA) therapy for patients with chronic hepatitis C virus (HCV) and substance use disorder (SUD) was assessed via a survey emailed throughout the United States to clinicians (physicians and advanced practice providers) in gastroenterology, hepatology, and infectious disease specialties. Clinicians' perceived barriers and preparedness and actions associated with current and future DAA prescribing practices of HCV-infected patients with SUD were assessed. Of 846 clinicians presumably receiving the survey, 96 completed and returned it. Exploratory factor analyses of perceived barriers indicated a highly reliable (Cronbach alpha = 0.89) model with five factors: HCV stigma and knowledge, prior authorization requirements, and patient- clinician-, and system-related barriers. In multivariable analyses, after controlling for covariates, patient-related barriers (P < 0.01) and prior authorization requirements (P < 0.01) were Conclusion: These findings underscore the importance of addressing patient-related barriers and prior authorization requirements-significant problematic barriers-and improving clinicians' beliefs (e.g., medication-assisted therapy should be prescribed before DAAs) and comfort levels for treating patients with HCV and SUD to enhance treatment access for patients with both HCV and SUD.

Indexed as

DAA, direct-acting antiviralDirect-acting antiviralsGHAPP, Gastroenterology & Hepatology Advanced Practice ProvidersHCVHCV, hepatitis C virusMedicaidPWID, persons who inject drugsSUDSUD, substance use disorderSurveyUS, United States

Identifiers

PMID36865395
PMCPMC9971512
OpenAlexW4320497876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.