Evidence map›Paper›PMID 36865338›Full record

ArticleResearch square2023

Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: Clinical efficacy and correlative analyses.

Marina Konopleva, Courtney DiNardo, Tushar Bhagat, Natalia Baran, Alessia Lodi, Kapil Saxena, Tianyu Cai, Xiaoping Su, Anna Skwarska, Veronica Guerra and 33 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

43 authors at 8 institutions in 1 country.

Marina KonoplevaThe University of Texas, MD Anderson Cancer Center.
Courtney DiNardoUT MD Anderson Cancer Center.ORCID 0000-0001-9003-0390
Tushar BhagatAlbert Einstein College of Medicine.
Natalia BaranThe University of Texas MD Anderson Cancer Center.ORCID 0000-0003-0618-4798
Alessia LodiCollege of Natural Sciences, The University of Texas at Austin.
Kapil SaxenaThe University of Texas, MD Anderson Cancer Center.
Tianyu CaiThe University of Texas, MD Anderson Cancer Center.
Xiaoping SuDan L. Duncan Cancer Center and , Baylor College of Medicine.
Anna SkwarskaAlbert Einstein College of Medicine-Montefiore Medical Center.
Veronica GuerraMD Anderson Cancer Center.
Vinitha KuruvillaThe University of Texas, MD Anderson Cancer Center.
Sergej KonoplevMD Anderson cancer Center, The University of Texas.
Shanisha Gordon-MitchellAlbert Einstein College of Medicine.
Kith PradhanAlbert Einstein College of Medicine.
Srinivas AluriAlbert Einstein College of Medicine.
Meghan CollinsCollege of Natural Sciences, The University of Texas at Austin.ORCID 0000-0002-6201-9298
Shannon SweeneyDepartment of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
Jonathan BusquetDell Medical School, The University of Texas at Austin.
Atul RathoreDell Medical School, The University of Texas at Austin.
Qing DengThe University of Texas MD Anderson Cancer Cent.
Michael GreenMD Anderson Cancer Centre.ORCID 0000-0001-6309-9472
Steven GrantDepartment of Medicine, Virginia Commonwealth University.
Susan DemoCalithera Biosciences.
Gaurav ChoudharyAlbert Einstein College of Medicine-Montefiore Medical Center.
Srabani SahuAlbert Einstein College of Medicine.
Beamon AgarwalGenomeRxUs LLC.
Mason SpodekAlbert Einstein College of Medicine-Montefiore Medical Center.
Victor ThiruthuvanathanAlbert Einstein College of Medicine.
Britta WillAlbert Einstein College of Medicine.
Ulrich SteidlAlbert Einstein College of Medicine.
George TippettThe University of Texas, MD Anderson Cancer Center.
Jan BurgerMD Anderson Cancer Center.
Gautam BorthakurThe University of Texas MD Anderson Cancer Center.ORCID 0000-0001-7679-6453
Elias JabbourThe University of Texas MD Anderson Cancer Center.
Naveen PemmarajuThe University of Texas, MD Anderson Cancer Center.
Tapan KadiaThe University of Texas MD Anderson Cancer Center.
Steven KomblauThe University of Texas MD Anderson Cancer Center.ORCID 0000-0002-5990-9548
Naval DaverThe University of Texas MD Anderson Cancer Center.ORCID 0000-0001-7103-373X
Kiran NaqviThe University of Texas, MD Anderson Cancer Center.
Nicholas ShortThe University of Texas, MD Anderson Cancer Center.
Guillermo Garcia-ManeroMD Anderson Cancer Center.ORCID 0000-0002-3631-2482
Stefano TizianiDepartment of Nutritional Sciences, Dell Pediatric Research Institute, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
Amit VermaMontefiore Einstein Cancer Center.
The University of Texas MD Anderson Cancer Center · USAlbert Einstein College of Medicine · USThe University of Texas at Austin · USScripps MD Anderson Cancer Center · USBaylor College of Medicine · USCalithera (United States) · USDNAnexus (United States) · USVirginia Commonwealth University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
University of Texas M.D. Anderson Cancer SPORE-LeukemiaP50CA100632 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI REZVANI, KATY · 2003 to 2023
$43.7M
Therapeutic targeting of glutamine metabolism in MDSR01CA206210 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KONOPLEVA, MARINA Y, TIZIANI, STEFANO · 2016 to 2020
$2.4M
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA100632NCI NIH HHS R01 CA206210
6 · The paper itself

Abstract

Malignancies can become reliant on glutamine as an alternative energy source and as a facilitator of aberrant DNA methylation, thus implicating glutaminase (GLS) as a potential therapeutic target. We demonstrate preclinical synergy of telaglenastat (CB-839), a selective GLS inhibitor, when combined with azacytidine (AZA),

Identifiers

PMID36865338
PMCPMC9980221
OpenAlexW4321606210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.