Evidence map›Paper›PMID 36865314›Full record

ArticlebioRxiv : the preprint server for biology2023

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity.

Chia-Hao Lin, Cheng-Jang Wu, Sunglim Cho, Rasika Patkar, Ling-Li Lin, Mei-Chi Chen, Elisabeth Israelsson, Joanne Betts, Magdalena Niedzielska, Shefali A Patel and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 2 countries.

Chia-Hao LinSchool of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA.
Cheng-Jang WuSchool of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA.
Sunglim ChoSchool of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA.
Rasika PatkarSchool of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA.
Ling-Li LinSchool of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA.
Mei-Chi ChenSchool of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA.
Elisabeth IsraelssonBioscience, Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Joanne BettsBioscience, Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Magdalena NiedzielskaBioscience, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Shefali A PatelDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Han G DuongDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Romana R GernerDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Chia-Yun HsuDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Matthew CatleyBioscience, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Rose A MaciewiczBioscience, Research and Early Development, Respiratory & Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Hiutung ChuDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Manuela RaffatelluDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
John T ChangDepartment of Medicine, University of California, San Diego, La Jolla, CA, USA.
Li-Fan LuSchool of Biological Sciences, University of California, San Diego, La Jolla, California , CA, USA.
University of California San Diego · USAstraZeneca (Sweden) · SE

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
Single-Cell Transcriptomic and Epigenetics CoreP01AI132122 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZUNIGA, ELINA I · 2018 to 2022
$9.8M
Role of microRNAs in regulatory T cell-mediated immunological tolerance and T celR01AI108651 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LU, LI-FAN · 2014 to 2024
$4.0M
C3-Dependent Intracellular Killing in Innate Immunity and Bacterial PathogenesisR01AI145325 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, RAFFATELLU, MANUELA · 2019 to 2023
$3.1M
Nutritional immunity during Salmonella infectionR01AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RAFFATELLU, MANUELA · 2016 to 2020
$1.9M
Nutritional immunity during Salmonella infectionR37AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Manuela Raffatellu · 2023 to 2026
$1.8M
The Microbiome Mediates Protections from Colitis Through Pathways Linked to IBDR00DK110534 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHU, HIUTUNG · 2018 to 2020
$744k
Antimicrobial activity of Escherichia coli Nissle 1917 microcin MR21AI154644 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NOLAN, ELIZABETH M, RAFFATELLU, MANUELA · 2020 to 2021
$440k
Functional dissection of the Klrg1+ regulatory T cell subset in health and diseasesR21AI163813 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LU, LI-FAN · 2021 to 2022
$435k
Specialization of regulatory T cell-mediated immune regulation during Toxoplasma infectionR56AI127751 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LU, LI-FAN · 2017 to 2017
$280k
The Microbiome Mediates Protections from Colitis Through Pathways Linked to IBDK99DK110534 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CHU, HIUTUNG · 2016 to 2017
$179k
Transcriptional regulation of T cell immunityI01BX005106 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI CHANG, JOHN T · 2021 to 2024
–
BLRD VA I01 BX005106NIAID NIH HHS P01 AI132122NIAID NIH HHS R01 AI108651NIAID NIH HHS R01 AI126277NIAID NIH HHS R01 AI145325NIAID NIH HHS R21 AI154644NIAID NIH HHS R21 AI163813NIAID NIH HHS R37 AI126277NIAID NIH HHS R56 AI127751NIDDK NIH HHS K99 DK110534NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R00 DK110534
6 · The paper itself

Abstract

Regulatory T (Treg) cells are instrumental in establishing immunological tolerance. However, the precise effector mechanisms by which Treg cells control a specific type of immune response in a given tissue remains unresolved. By simultaneously studying Treg cells from different tissue origins under systemic autoimmunity, here we show that IL-27 is specifically produced by intestinal Treg cells to regulate Th17 immunity. Selectively increased intestinal Th17 responses in mice with Treg cell-specific IL-27 ablation led to exacerbated intestinal inflammation and colitis-associated cancer, but also helped protect against enteric bacterial infection. Furthermore, single-cell transcriptomic analysis has identified a CD83

Identifiers

PMID36865314
PMCPMC9980002
OpenAlexW4321434272

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.