Evidence map›Paper›PMID 36865303›Full record

ArticleResearch square2023

CELA1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency.

Andrew J Devine, Noah J Smith, Rashika Joshi, Qiang Fan, Michael T Borchers, Geremy C Clair, Joshua N Adkins, Brian M Varisco

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Andrew J DevineCincinnati Children's Hospital Medical Center.
Noah J SmithUniversity of Cincinnati College of Medicine.
Rashika JoshiCincinnati Children's Hospital Medical Center.
Qiang FanCincinnati Children's Hospital Medical Center.
Michael T BorchersUniversity of Cincinnati College of Medicine.
Geremy C ClairPacific Northwest National Laboratory.
Joshua N AdkinsPacific Northwest National Laboratory.
Brian M VariscoCincinnati Children's Hospital Medical Center.
Cincinnati Children's Hospital Medical Center · USPacific Northwest National Laboratory · US

Funding

Research Center for Spatiotemporal Lung Imaging and OmicsU01HL148860 · NHLBI · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI ADKINS, JOSHUA N., CARSON, JAMES PAUL · 2019 to 2023
$4.7M
Chymotrypsin-like Elastase 1 in Lung Development and DiseaseR01HL141229 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI ZINGARELLI, BASILIA · 2018 to 2022
$2.6M
Clec5a regulation of Macrophage function in COPDR01HL119538 · NHLBI · UNIVERSITY OF CINCINNATI · PI BORCHERS, MICHAEL · 2014 to 2017
$1.6M
Cela1 Mediates Stretch-regulated Elastin Remodeling During Alveolar SeptationK08HL131261 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI VARISCO, BRIAN MICHAEL · 2016 to 2019
$599k
Natural Killer Cell Functions in COPDI01BX002347 · VA · CINCINNATI VA MEDICAL CENTER RESEARCH · PI BORCHERS, MICHAEL · 2015 to 2018
–
BLRD VA I01 BX002347NHLBI NIH HHS K08 HL131261NHLBI NIH HHS R01 HL119538NHLBI NIH HHS R01 HL141229NHLBI NIH HHS U01 HL148860
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID36865303
PMCPMC9980203
OpenAlexW4321605829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.