Evidence map›Paper›PMID 36865244›Full record

ArticlebioRxiv : the preprint server for biology2023

Parinya Samakkarnthai, Dominik Saul, Lei Zhang, Zaira Aversa, Madison L Doolittle, Jad G Sfeir, Japneet Kaur, Elizabeth J Atkinson, James R Edwards, R Graham G Russell and 9 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    2023
5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

Parinya SamakkarnthaiORCID 0000-0003-0695-9960
Lei Zhang
Zaira Aversa
Madison L DoolittleORCID 0000-0003-0912-0095
Elizabeth J AtkinsonORCID 0000-0002-1191-3775
James R Edwards
R Graham G RussellORCID 0000-0002-4136-1828
James L Kirkland
Laura J NiedernhoferORCID 0000-0002-1074-1385
Nathan K LeBrasseurORCID 0000-0002-2002-0418
Mayo Clinic in Arizona · USMayo Clinic in Florida · USUniversity of Minnesota · USNuffield Orthopaedic Centre · GBMayo Clinic · USPhramongkutklao Hospital · TH

Funding

The Role of miR-219a-5p in Bone MetabolismR01AG063707 · NIA · MAYO CLINIC ROCHESTER · PI MONROE, DAVID G · 2020 to 2024
$1.5M
NIA NIH HHS R01 AG063707
6 · The paper itself

Abstract

In addition to reducing fracture risk, zoledronate has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals. Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the non-skeletal actions of zoledronate could be due to senolytic (killing of senescent cells) or senomorphic (inhibition of the secretion of the senescence-associated secretory phenotype [SASP]) actions. To test this, we first performed

Identifiers

PMID36865244
PMCPMC9980119
OpenAlexW4321769721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.