Evidence map›Paper›PMID 36865195›Full record

ArticlebioRxiv : the preprint server for biology2023

Low-threshold, high-resolution, chronically stable intracortical microstimulation by ultraflexible electrodes.

Roy Lycke, Robin Kim, Pavlo Zolotavin, Jon Montes, Yingchu Sun, Aron Koszeghy, Esra Altun, Brian Noble, Rongkang Yin, Fei He and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 3 countries.

Roy LyckeDepartment of Electrical and Computer Engineering; Rice University; Houston; Texas; 77005, United States.
Robin KimDepartment of Electrical and Computer Engineering; Rice University; Houston; Texas; 77005, United States.
Pavlo ZolotavinDepartment of Electrical and Computer Engineering; Rice University; Houston; Texas; 77005, United States.
Jon MontesRice Neuroengineering Initiative; Rice University; Houston; Texas; 77005, United States.
Yingchu SunDepartment of Electrical and Computer Engineering; Rice University; Houston; Texas; 77005, United States.
Aron KoszeghyHelsinki Institute of Life Science (HiLIFE); University of Helsinki; Helsinki; 00790; Finland.
Esra AltunRice Neuroengineering Initiative; Rice University; Houston; Texas; 77005, United States.
Brian NobleRice Neuroengineering Initiative; Rice University; Houston; Texas; 77005, United States.
Rongkang YinDepartment of Electrical and Computer Engineering; Rice University; Houston; Texas; 77005, United States.
Fei HeDepartment of Electrical and Computer Engineering; Rice University; Houston; Texas; 77005, United States.
Nelson TotahHelsinki Institute of Life Science (HiLIFE); University of Helsinki; Helsinki; 00790; Finland.
Chong XieDepartment of Electrical and Computer Engineering; Rice University; Houston; Texas; 77005, United States.
Lan LuanDepartment of Electrical and Computer Engineering; Rice University; Houston; Texas; 77005, United States.
ATLAS Neuroengineering (Belgium) · BEUniversity of Helsinki · FI

Funding

Maximizing flexibility: Optimized neural probes and electronics for long term, high bandwidth recordingsU01NS115588 · NINDS · RICE UNIVERSITY · PI FRANK, LOREN M, XIE, CHONG · 2020 to 2023
$4.6M
Longitudinal multimodal mapping to decipher the neurovascular impact of microinfarctsR01NS109361 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI LUAN, LAN · 2019 to 2023
$2.9M
NINDS NIH HHS R01 NS109361NINDS NIH HHS U01 NS115588
6 · The paper itself

Abstract

Intracortical microstimulation (ICMS) enables applications ranging from neuroprosthetics to causal circuit manipulations. However, the resolution, efficacy, and chronic stability of neuromodulation is often compromised by the adverse tissue responses to the indwelling electrodes. Here we engineer ultraflexible stim-Nanoelectronic Threads (StimNETs) and demonstrate low activation threshold, high resolution, and chronically stable ICMS in awake, behaving mouse models.

Identifiers

PMID36865195
PMCPMC9980065
OpenAlexW4321434327

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.