Evidence map›Paper›PMID 36865176›Full record

ArticlebioRxiv : the preprint server for biology2023

Myomatrix arrays for high-definition muscle recording.

Bryce Chung, Muneeb Zia, Kyle A Thomas, Jonathan A Michaels, Amanda Jacob, Andrea Pack, Matthew J Williams, Kailash Nagapudi, Lay Heng Teng, Eduardo Arrambide and 42 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

52 authors.

Bryce ChungDepartment of Biology, Emory University (Atlanta, GA, USA).
Muneeb ZiaSchool of Electrical and Computer Engineering, Georgia Institute of Technology (Atlanta, GA, USA).
Kyle A ThomasGraduate Program in Biomedical Engineering at Emory University and Georgia Tech (Atlanta, GA, USA).
Jonathan A MichaelsDepartment of Physiology and Pharmacology, Western University (London, ON, Canada).
Amanda JacobDepartment of Biology, Emory University (Atlanta, GA, USA).
Andrea PackNeuroscience Graduate Program, Emory University (Atlanta, GA, USA).
Matthew J WilliamsGraduate Program in Biomedical Engineering at Emory University and Georgia Tech (Atlanta, GA, USA).
Kailash NagapudiDepartment of Biology, Emory University (Atlanta, GA, USA).
Lay Heng TengDepartment of Biology, Emory University (Atlanta, GA, USA).
Eduardo ArrambideDepartment of Biology, Emory University (Atlanta, GA, USA).
Logan OuelletteDepartment of Biology, Emory University (Atlanta, GA, USA).
Nicole OeyDepartment of Biology, Emory University (Atlanta, GA, USA).
Rhuna GibbsDepartment of Biology, Emory University (Atlanta, GA, USA).
Philip AnschutzGraduate Program in BioEngineering, Georgia Tech (Atlanta, GA, USA).
Jiaao LuGraduate Program in Electrical and Computer Engineering, Georgia Tech (Atlanta, GA, USA).
Yu WuSchool of Electrical and Computer Engineering, Georgia Institute of Technology (Atlanta, GA, USA).
Mehrdad KashefiDepartment of Physiology and Pharmacology, Western University (London, ON, Canada).
Tomomichi OyaDepartment of Physiology and Pharmacology, Western University (London, ON, Canada).
Rhonda KerstenDepartment of Physiology and Pharmacology, Western University (London, ON, Canada).
Alice C MosbergerZuckerman Mind Brain Behavior Institute at Columbia University (New York, NY, USA).
Sean O'ConnellGraduate Program in Biomedical Engineering at Emory University and Georgia Tech (Atlanta, GA, USA).
Runming WangDepartment of Biomedical Engineering at Emory University and Georgia Tech (Atlanta, GA, USA).
Hugo MarquesChampalimaud Neuroscience Programme, Champalimaud Foundation (Lisbon, Portugal).
Ana Rita MendesChampalimaud Neuroscience Programme, Champalimaud Foundation (Lisbon, Portugal).
Constanze LenschowChampalimaud Neuroscience Programme, Champalimaud Foundation (Lisbon, Portugal).
Gayathri KondakathDepartment of Biology, Tufts University (Medford, MA, USA).
Jeong Jun KimSolomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine (Baltimore, MD, USA).
William OlsonSolomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine (Baltimore, MD, USA).
Kiara N QuinnDepartments of Biomedical Engineering and Neurology, Johns Hopkins School of Medicine (Baltimore, MD, USA).
Pierce PerkinsDepartments of Biomedical Engineering and Neurology, Johns Hopkins School of Medicine (Baltimore, MD, USA).
Graziana GattoSalk Institute for Biological Studies (La Jolla, CA, USA).
Ayesha ThanawallaSalk Institute for Biological Studies (La Jolla, CA, USA).
Susan ColtmanDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus (Aurora, CO, USA).
Taegyo KimDepartment of Neurobiology & Anatomy, Drexel University, College of Medicine (Philadelphia, PA, USA).
Trevor SmithDepartment of Neurobiology & Anatomy, Drexel University, College of Medicine (Philadelphia, PA, USA).
Ben Binder-MarkeyDepartment of Physical Therapy and Rehabilitation Sciences, Drexel University College of Nursing and Health Professions (Philadelphia, PA).
Martin ZabackDepartment of Health and Rehabilitation Sciences, Temple University (Philadelphia, PA, USA).
Christopher K ThompsonDepartment of Health and Rehabilitation Sciences, Temple University (Philadelphia, PA, USA).
Simon GiszterDepartment of Neurobiology & Anatomy, Drexel University, College of Medicine (Philadelphia, PA, USA).
Abigail PersonDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus (Aurora, CO, USA).
Martyn GouldingSalk Institute for Biological Studies (La Jolla, CA, USA).
Eiman AzimSalk Institute for Biological Studies (La Jolla, CA, USA).
Nitish ThakorDepartments of Biomedical Engineering and Neurology, Johns Hopkins School of Medicine (Baltimore, MD, USA).
Daniel O'ConnorSolomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine (Baltimore, MD, USA).
Barry TrimmerDepartment of Biology, Tufts University (Medford, MA, USA).
Susana Q LimaChampalimaud Neuroscience Programme, Champalimaud Foundation (Lisbon, Portugal).
Megan R CareyChampalimaud Neuroscience Programme, Champalimaud Foundation (Lisbon, Portugal).
Chethan PandarinathDepartment of Biomedical Engineering at Emory University and Georgia Tech (Atlanta, GA, USA).
Rui M CostaZuckerman Mind Brain Behavior Institute at Columbia University (New York, NY, USA).
J Andrew PruszynskiDepartment of Physiology and Pharmacology, Western University (London, ON, Canada).
Muhannad BakirSchool of Electrical and Computer Engineering, Georgia Institute of Technology (Atlanta, GA, USA).
Samuel J SoberDepartment of Biology, Emory University (Atlanta, GA, USA).

Funding

Modeling multi-area dynamics during motor controlU19NS104649 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COSTA, RUI M. · 2017 to 2021
$15.3M
Spinal Circuits for the Control of Dextrous MovementU19NS112959 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2019 to 2023
$14.3M
Spinal circuits for mechanical itch and light touchR35NS111643 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Martyn D Goulding · 2019 to 2026
$9.7M
Crucial spinal circuit changes that mediate locomotor benefits and deficits following combined therapies after spinal cord injuryR01NS104194 · NINDS · DREXEL UNIVERSITY · PI Kimberly J Dougherty, SIMON F GISZTER · 2018 to 2026
$4.2M
Norepinephrine modulation of neocortex during flexible behaviorR01NS104834 · NINDS · JOHNS HOPKINS UNIVERSITY · PI COHEN, JEREMIAH YAACOV, O'CONNOR, DANIEL HANS · 2018 to 2022
$4.1M
Vocal motor control and sensorimotor learning - behavior, muscles, and neuronsR01NS084844 · NINDS · EMORY UNIVERSITY · PI SOBER, SAMUEL · 2013 to 2023
$3.8M
Next-Generation Tools to Measure and Manipulate Muscle Activity Across Species and BehaviorsR01NS109237 · NINDS · EMORY UNIVERSITY · PI Muhannad Bakir, Samuel Sober · 2019 to 2026
$3.8M
Neural control of skilled movements: an ethological dissection of genetically tractable mammalian motor circuitsDP2NS105555 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2017 to 2022
$3.7M
Center for Advanced Muscle BioElectronics (CAMBER)U24NS126936 · NINDS · EMORY UNIVERSITY · PI Samuel Sober · 2023 to 2026
$3.5M
Defining the anatomical, molecular and functional logic of internal copy circuits involved in dexterous forelimb behaviorsR01NS111479 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2019 to 2023
$2.9M
Fusing motor neuroscience and artificial intelligence to create next-generation neural prostheses.DP2NS127291 · NINDS · EMORY UNIVERSITY · PI PANDARINATH, CHETHAN · 2021 to 2024
$2.4M
Functional dissection of cerebellar output circuits that orchestrate limb motor controlRF1NS128898 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN, CHEN, ALBERT · 2022 to 2022
$2.3M
NIBIB NIH HHS R01 EB022872NIMH NIH HHS F32 MH120873NINDS NIH HHS DP2 NS105555NINDS NIH HHS DP2 NS127291NINDS NIH HHS F31 NS124347NINDS NIH HHS K99 NS126307NINDS NIH HHS R01 NS084844NINDS NIH HHS R01 NS099375NINDS NIH HHS R01 NS104194NINDS NIH HHS R01 NS104834NINDS NIH HHS R01 NS109237NINDS NIH HHS R01 NS111479NINDS NIH HHS R01 NS124820NINDS NIH HHS R35 NS111643NINDS NIH HHS RF1 NS128898NINDS NIH HHS U19 NS104649NINDS NIH HHS U19 NS112959NINDS NIH HHS U24 NS126936
6 · The paper itself

Abstract

Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding of motor control has grown rapidly thanks to new methods for recording and analyzing populations of many individual neurons over time. In contrast, current methods for recording the nervous system's actual motor output - the activation of muscle fibers by motor neurons - typically cannot detect the individual electrical events produced by muscle fibers during natural behaviors and scale poorly across species and muscle groups. Here we present a novel class of electrode devices ("Myomatrix arrays") that record muscle activity at unprecedented resolution across muscles and behaviors. High-density, flexible electrode arrays allow for stable recordings from the muscle fibers activated by a single motor neuron, called a "motor unit", during natural behaviors in many species, including mice, rats, primates, songbirds, frogs, and insects. This technology therefore allows the nervous system's motor output to be monitored in unprecedented detail during complex behaviors across species and muscle morphologies. We anticipate that this technology will allow rapid advances in understanding the neural control of behavior and in identifying pathologies of the motor system.

Identifiers

PMID36865176
PMCPMC9980060

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.