Evidence map›Paper›PMID 36865129›Full record

ArticlebioRxiv : the preprint server for biology2023

cGLRs are a diverse family of pattern recognition receptors in animal innate immunity.

Yao Li, Kailey M Slavik, Benjamin R Morehouse, Carina C de Oliveira Mann, Kepler Mears, Jingjing Liu, Dmitry Kashin, Frank Schwede, Philip J Kranzusch

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yao LiDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Kailey M SlavikDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Benjamin R MorehouseDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Carina C de Oliveira MannInstitute of Virology, Technical University of Munich, 81675 Munich, Germany.
Kepler MearsDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Jingjing LiuDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Dmitry KashinBiolog Life Science Institute GmbH & Co. KG, Flughafendamm 9a, 28199 Bremen, Germany.
Frank SchwedeBiolog Life Science Institute GmbH & Co. KG, Flughafendamm 9a, 28199 Bremen, Germany.
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
Harvard University · USBiolog Life Science Institute · DEDana-Farber Cancer Institute · USTechnical University of Munich · DE

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Discovery of cGAS-like signaling enzymes in innate immunity and diseaseDP2GM146250 · NIGMS · DANA-FARBER CANCER INST · PI KRANZUSCH, PHILIP J · 2021 to 2024
$2.5M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
Mechanism of activation of a new cGAS-like enzyme in humansF32GM133063 · NIGMS · DANA-FARBER CANCER INST · PI MOREHOUSE, BENJAMIN ROBERT · 2019 to 2020
$127k
Discovery of diverse nucleotide immune signals for use as novel immunotherapiesF99CA274660 · NCI · HARVARD MEDICAL SCHOOL · PI SLAVIK, KAILEY · 2022 to 2022
$36k
NCI NIH HHS F99 CA274660NCRR NIH HHS S10 RR029205NIGMS NIH HHS DP2 GM146250NIGMS NIH HHS F32 GM133063NIGMS NIH HHS P30 GM124165NIH HHS S10 OD021527
6 · The paper itself

Abstract

cGAS (cyclic GMP-AMP synthase) is an enzyme in human cells that controls an immune response to cytosolic DNA. Upon binding DNA, cGAS synthesizes a nucleotide signal 2'3'-cGAMP that activates the protein STING and downstream immunity. Here we discover cGAS-like receptors (cGLRs) constitute a major family of pattern recognition receptors in animal innate immunity. Building on recent analysis in

Identifiers

PMID36865129
PMCPMC9980059
OpenAlexW4321486642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.