Evidence map›Paper›PMID 36865118›Full record

ArticlebioRxiv : the preprint server for biology2024

Mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane: a new indirect mechanism driving tissue necrosis in

Louise Tzung-Harn Hsieh, Belinda S Hall, Jane Newcombe, Tom A Mendum, Sonia Santana-Varela, Yagnesh Umrania, Michael J Deery, Wei Q Shi, Josué Diaz-Delgado, Francisco J Salguero and 1 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

  • Updated by
    The2025
5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Louise Tzung-Harn HsiehDept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey.
Belinda S HallDept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey.
Jane NewcombeDept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey.
Tom A MendumDept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey.
Sonia Santana-VarelaDept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey.
Yagnesh UmraniaCambridge Centre for Proteomics, University of Cambridge, Cambridge, UK.
Michael J DeeryCambridge Centre for Proteomics, University of Cambridge, Cambridge, UK.
Wei Q ShiDepartment of Chemistry, Ball State University, Muncie, IN 47306, USA.
Josué Diaz-DelgadoTexas A&M Veterinary Medical Diagnostic Laboratory, College Station, Texas, USA.ORCID 0000-0001-5281-0521
Francisco J SalgueroUnited Kingdom Health Security Agency. UKHSA-Porton Down, Salisbury, U.K.
Rachel E SimmondsDept of Microbial Sciences, School of Bioscience and Medicine, University of Surrey.ORCID 0000-0003-4843-8266
University of Surrey · GBUniversity of Cambridge · GBBall State University · USDefence Science and Technology Laboratory · GBWellborn Road Veterinary Medical Center · US

Funding

Medicinal Chemistry and Chemical Proteomics of Ipomoeassin Natural GlycoresinsR15GM116032 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI SHI, WEI · 2015 to 2020
$767k
NIGMS NIH HHS R15 GM116032Wellcome Trust 202843/Z/16/Z
6 · The paper itself

Abstract

The drivers of tissue necrosis in

Identifiers

PMID36865118
PMCPMC9980099
OpenAlexW4321433670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.