Evidence map›Paper›PMID 36865115›Full record

ArticleResearch square2023

13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue.

Alexander M Barclay, Dhruva D Dhavale, Collin G Borcik, Moses H Milchberg, Paul T Kotzbauer, Chad M Rienstra

Abstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    2023
5 · Who and what money

Authors and funding

6 authors.

Alexander M BarclayUniversity of Illinois at Urbana-Champaign.
Dhruva D DhavaleWashington University School of Medicine.
Collin G BorcikUniversity of Wisconsin-Madison.
Moses H MilchbergUniversity of Wisconsin-Madison.
Paul T KotzbauerWashington University School of Medicine.
Chad M RienstraUniversity of Wisconsin-Madison.

Funding

INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
Technologies for Solid-State NMR Data CollectionP41GM136463 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HENZLER-WILDMAN, KATHERINE ANNE, RIENSTRA, CHAD M · 2021 to 2025
$6.4M
Protein Aggregation and Neurotransmitter Deficits in Parkinson DiseaseR01NS097799 · NINDS · WASHINGTON UNIVERSITY · PI PAUL T KOTZBAUER · 2016 to 2026
$5.8M
Structural Biology of Alpha-Synuclein in Lewy Body DementiaRF1NS110436 · NINDS · WASHINGTON UNIVERSITY · PI KOTZBAUER, PAUL T, RIENSTRA, CHAD M · 2023 to 2023
$4.2M
STRUCTURAL BIOLOGY OF ALPHA-SYNUCLEIN IN LEWY BODY DEMENTIAU01NS110436 · NINDS · WASHINGTON UNIVERSITY · PI KOTZBAUER, PAUL T · 2018 to 2022
$4.1M
Investigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3M
NIGMS NIH HHS P41 GM136463NINDS NIH HHS R01 NS075321NINDS NIH HHS R01 NS097799NINDS NIH HHS RF1 NS075321NINDS NIH HHS RF1 NS110436NINDS NIH HHS U01 NS110436
6 · The paper itself

Abstract

Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of

Indexed as

FibrilsLewy Body DementiaParkinson DiseasePolymorphismα-Synuclein

Identifiers

PMID36865115
PMCPMC9980205

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.