Evidence map›Paper›PMID 36864958›Full record

ArticleCardiovascular diagnosis and therapy2023

Diagnostic performance of contemporary transesophageal echocardiography with modern imaging for infective endocarditis.

Bryce Montané, Johnny Chahine, Andrew Fiore, Jafar Alzubi, Hanan Alnajjar, Jasmine Mutti, Richard A Grimm, Brian P Griffin, Bo Xu

Abstract read
In one paragraph

Article in Cardiovascular diagnosis and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Infective endocarditis associated with left atrial appendage occlusion device: a contemporary systematic review.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024
    Pooled it
  2. Pooled it
  3. Mitral valve abscess: echocardiographic imaging, microbiology, management, and outcomes.European heart journal. Imaging methods and practice · 2026
    Article
  4. Article
  5. Review
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  8. Infective Endocarditis: A Never-Ending Ordeal?Arquivos brasileiros de cardiologia · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bryce Montané *Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
Johnny Chahine *Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
Andrew FioreDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
Jafar AlzubiDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
Hanan AlnajjarDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
Jasmine MuttiDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
Richard A GrimmSection of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Brian P GriffinSection of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Bo XuSection of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Infective endocarditis (IE) is associated with high morbidity and mortality. Following an initial negative transesophageal echocardiogram (TEE), high clinical suspicion warrants repeat examination. We evaluated the diagnostic performance of contemporary TEE imaging for IE. Methods: This retrospective cohort study included patients ≥18 years old undergoing ≥2 TEEs within 6 months, with confirmed diagnosis of IE based on Duke criteria, 70 in 2011 and 172 in 2019, were included. We compared the diagnostic performance of TEE for IE in 2019 versus 2011. The primary endpoint was the sensitivity of initial TEE to detect IE. Results: Sensitivity of the initial TEE to detect endocarditis was 85.7% versus 95.3%, in 2011 and 2019, respectively (P=0.01). On multivariable analysis, initial TEE more frequently detected IE in 2019, compared to 2011 [odds ratio (OR): 4.06, 95% confidence intervals (CIs): 1.41-11.71, P=0.01]. Improved diagnostic performance was driven by improved detection of prosthetic valve infective endocarditis (PVIE), sensitivity 70.8% in 2011 versus 93.7% (P=0.009) in 2019. In 2019, TEEs more frequently utilized probes with higher frame rates/resolution, than 2011 (P<0.001). Three dimensional (3D) technology was utilized in 97.2% of initial TEEs in 2019, compared to 70.5% in 2011 (P<0.001). Conclusions: Contemporary TEE was associated with improved diagnostic performance for endocarditis, driven by improved sensitivity for PVIE.

Indexed as

Echocardiographyinfective endocarditis (IE)three dimensional echocardiographytransesophageal echocardiography (TEE)valvular heart disease

Identifiers

PMID36864958
PMCPMC9971297

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.