Evidence map›Paper›PMID 36864917›Full record

ArticleFrontiers in neurology2023

Bacteria commonly associated with central nervous system catheter infections elicit distinct CSF proteome signatures.

Matthew Beaver, Dragana Noe, Ishwor Thapa, Hesham Ali, Jessica Snowden, Tammy Kielian, Gwenn L Skar

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Matthew BeaverDepartment of Pediatrics, University of Nebraska Medical Center, Omaha, NE, United States.
Dragana NoeMass Spectrometry and Proteomics Core Facility, University of Nebraska Medical Center, Omaha, NE, United States.
Ishwor ThapaCollege of Information Science and Technology, University of Nebraska Omaha, Omaha, NE, United States.
Hesham AliCollege of Information Science and Technology, University of Nebraska Omaha, Omaha, NE, United States.
Jessica SnowdenDepartments of Pediatrics and Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Tammy KielianDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States.
Gwenn L SkarDepartment of Pediatrics, University of Nebraska Medical Center, Omaha, NE, United States.
University of Nebraska Medical Center · USUniversity of Nebraska at Omaha · USUniversity of Arkansas for Medical Sciences · US

Funding

The Role of Complement in Cerebrospinal Fluid Shunt InfectionsK08NS110923 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SKAR, GWENN L · 2020 to 2024
$967k
NINDS NIH HHS K08 NS110923
6 · The paper itself

Abstract

Background: Cerebrospinal fluid (CSF) shunt infection is a common and devastating complication of the treatment of hydrocephalus. Timely and accurate diagnosis is essential as these infections can lead to long-term neurologic consequences including seizures, decreased intelligence quotient (IQ) and impaired school performance in children. Currently the diagnosis of shunt infection relies on bacterial culture; however, culture is not always accurate since these infections are frequently caused by bacteria capable of forming biofilms, such as Methods: To investigate potential biomarkers that would discriminate Results: Conclusions: Despite the differences in the CSF proteome with each organism compared to sterile injury, several proteins were common across all bacterial species, especially at day 5 post-infection, which are candidate diagnostic biomarkers.

Indexed as

biomarkerC. acnescentral nervous system infectioncerebrospinal fluidP. aeruginosaproteomeS. epidermidisshunt infection

Identifiers

PMID36864917
PMCPMC9971802
OpenAlexW4320723303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.