ArticleFrontiers in cellular and infection microbiology2023
The transmembrane domains of the type III secretion system effector Tir are involved in its secretion and cellular activities.
Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Milk-derived peptone reduces EHEC virulence by inhibiting the type III secretion system.Virulence · 2026Article
- Imported Retail Beef and Chicken Meat Products Serve as Reservoirs for Emerging Antibiotic-Resistant Pathotypes of Escherichia coli in Pristine Areas Free From Agricultural Activity.MicrobiologyOpen · 2026Article
- Gut microbiome-derived indoles differentially suppress type III secretion system-associated virulence inFrontiers in microbiology · 2026Article
- Genomic Characterization ofMicroorganisms · 2025Article
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3 authors.
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Abstract
Introduction: Enteropathogenic Methods: We created Tir TMD variants with the original or alternative TMD sequence. Results: We found that the C-terminal TMD of Tir (TMD2) is critical for the ability of Tir to escape integration into the bacterial membrane. However, the TMD sequence was not by itself sufficient and its effect was context-dependent. Moreover, the N-terminal TMD of Tir (TMD1) was important for the postsecretion function of Tir at the host cell. Discussion: Taken together, our study further supports the hypothesis that the TMD sequences of translocated proteins encode information crucial for protein secretion and their postsecretion function.
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