Evidence map›Paper›PMID 36864654›Full record

Trial reportDiabetes, obesity & metabolism2023

Effect of gastric distension with concurrent small intestinal saline or glucose infusion on incretin hormone secretion in healthy individuals: A randomized, controlled, crossover study.

Ryan J Jalleh, Laurence G Trahair, Tongzhi Wu, Scott Standfield, Christine Feinle-Bisset, Christopher K Rayner, Michael Horowitz, Karen L Jones

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, obesity & metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ryan J JallehAdelaide Medical School, The University of Adelaide, Adelaide, Australia.ORCID 0000-0003-4969-4771
Laurence G TrahairAdelaide Medical School, The University of Adelaide, Adelaide, Australia.
Tongzhi WuAdelaide Medical School, The University of Adelaide, Adelaide, Australia.ORCID 0000-0003-1656-9210
Scott StandfieldAdelaide Medical School, The University of Adelaide, Adelaide, Australia.
Christine Feinle-BissetAdelaide Medical School, The University of Adelaide, Adelaide, Australia.ORCID 0000-0001-6848-0125
Christopher K RaynerAdelaide Medical School, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-5527-256X
Michael HorowitzAdelaide Medical School, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-0942-0306
Karen L JonesAdelaide Medical School, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-1155-5816
Royal Adelaide Hospital · AUThe University of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the effect of gastric distension, induced using a gastric 'barostat', on the secretion of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in the presence and absence of small intestinal nutrients in healthy individuals. MATERIALS AND

methodsEight healthy participants (two females, six males, mean age 69.3 ± 1.2 years, body mass index 23.5 ± 0.8 kg/m

resultsFollowing intraduodenal saline or glucose infusion, there was no difference in plasma GLP-1 with or without gastric distension (P = 1.00 for both saline and glucose infusions). There was also no difference in plasma GIP with or without gastric distension (P = 1.00 for saline infusion and P = .99 for glucose infusion).

conclusionsGastric distension, either alone or during small intestinal glucose exposure, does not stimulate incretin hormone secretion significantly in healthy humans.

Indexed as

Gastric BalloonGlucoseAgedBlood GlucoseCross-Over StudiesFemaleGastric Inhibitory PolypeptideGlucagon-Like Peptide 1HumansIncretinsInsulinMaleSaline SolutionBlood GlucoseGastric Inhibitory PolypeptideGlucagon-Like Peptide 1GlucoseIncretinsInsulinSaline Solutionbarostatgastric distensionglucagon-like peptide-1glucose-dependent insulinotropic polypeptideincretinintragastric balloon

Identifiers

PMID36864654
PMCPMC10947269
OpenAlexW4323037461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.