Evidence map›Paper›PMID 36864621›Full record

ArticleAdvanced healthcare materials2023

Biodegradable Poly(ester) Urethane Acrylate Resins for Digital Light Processing: From Polymer Synthesis to 3D Printed Tissue Engineering Constructs.

Rong Wang, Febriyani Damanik, Tobias Kuhnt, Armand Jaminon, Shahzad Hafeez, Hong Liu, Hans Ippel, Pieter J Dijkstra, Nicole Bouvy, Leon Schurgers and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Rong WangDepartment of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.
Febriyani DamanikDepartment of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.
Tobias KuhntDepartment of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.
Armand JaminonSchool for Cardiovascular Diseases, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, 6229 ER, The Netherlands.
Shahzad HafeezDepartment of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.
Hong LiuDepartment of Surgery, Maastricht University Medical Center, Maastricht, 6229 HX, The Netherlands.
Hans IppelSchool for Cardiovascular Diseases, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, 6229 ER, The Netherlands.
Pieter J DijkstraDepartment of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.
Nicole BouvyDepartment of Surgery, Maastricht University Medical Center, Maastricht, 6229 HX, The Netherlands.
Leon SchurgersSchool for Cardiovascular Diseases, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, 6229 ER, The Netherlands.
A Tessa Ten CateDepartment of Materials for Additive Manufacturing, TNO, P.O. Box 6235, Eindhoven, 5600 HE, The Netherlands.
Aylvin DiasDSM Biomedical, DSM, Koestraat 1, Geleen, 6167 RA, The Netherlands.
Lorenzo MoroniDepartment of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.
Matthew B BakerDepartment of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.ORCID 0000-0003-1731-3858
Maastricht University · NLMaastricht University Medical Centre · NLDSM (Netherlands) · NLNetherlands Organisation for Applied Scientific Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Digital light processing (DLP) is an accurate and fast additive manufacturing technique to produce a variety of products, from patient-customized biomedical implants to consumer goods. However, DLP's use in tissue engineering has been hampered due to a lack of biodegradable resin development. Herein, a library of biodegradable poly(esters) capped with urethane acrylate (with variations in molecular weight) is investigated as the basis for DLP printable resins for tissue engineering. The synthesized oligomers show good printability and are capable of creating complex structures with mechanical moduli close to those of medium-soft tissues (1-3 MPa). While fabricated films from different molecular weight resins show few differences in surface topology, wettability, and protein adsorption, the adhesion and metabolic activity of NCTC clone 929 (L929) cells and human dermal fibroblasts (HDFs) are significantly different. Resins from higher molecular weight oligomers provide greater cell adhesion and metabolic activity. Furthermore, these materials show compatibility in a subcutaneous in vivo pig model. These customizable, biodegradable, and biocompatible resins show the importance of molecular tuning and open up new possibilities for the creation of biocompatible constructs for tissue engineering.

Indexed as

PolymersTissue EngineeringAcrylic ResinsAnimalsEstersHumansPolyurethanesPrinting, Three-DimensionalSwineAcrylic ResinsEstersPolymersPolyurethanesurethane acrylatebiofabricationDLP printingpoly(ester)polymer synthesis

Identifiers

PMID36864621
PMCPMC11481055
OpenAlexW4323035165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.