Evidence map›Paper›PMID 36864599›Full record

ArticleInternational journal for numerical methods in biomedical engineering2023

Effect of biomaterial stiffness on cardiac mechanics in a biventricular infarcted rat heart model with microstructural representation of in situ intramyocardial injectate.

Y D Motchon, Kevin L Sack, M S Sirry, M Kruger, E Pauwels, D Van Loo, A De Muynck, L Van Hoorebeke, Neil H Davies, Thomas Franz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal for numerical methods in biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 5 countries.

Y D MotchonBiomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Kevin L SackBiomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
M S SirryDepartment of Biomedical Engineering, School of Engineering and Computing, American International University, Al Jahra, Kuwait.
M KrugerCardiovascular Research Unit, MRC IUCHRU, University of Cape Town, Cape Town, South Africa.
E PauwelsCentre for X-ray Tomography, Department of Physics and Astronomy, Ghent University, Ghent, Belgium.
D Van LooCentre for X-ray Tomography, Department of Physics and Astronomy, Ghent University, Ghent, Belgium.
A De MuynckCentre for X-ray Tomography, Department of Physics and Astronomy, Ghent University, Ghent, Belgium.
L Van HoorebekeCentre for X-ray Tomography, Department of Physics and Astronomy, Ghent University, Ghent, Belgium.
Neil H DaviesCardiovascular Research Unit, MRC IUCHRU, University of Cape Town, Cape Town, South Africa.
Thomas FranzBiomedical Engineering Research Centre, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-1504-3842
University of Cape Town · ZAGhent University Hospital · BEJahra Hospital · KW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intramyocardial delivery of biomaterials is a promising concept for treating myocardial infarction. The delivered biomaterial provides mechanical support and attenuates wall thinning and elevated wall stress in the infarct region. This study aimed at developing a biventricular finite element model of an infarcted rat heart with a microstructural representation of an in situ biomaterial injectate, and a parametric investigation of the effect of the injectate stiffness on the cardiac mechanics. A three-dimensional subject-specific biventricular finite element model of a rat heart with left ventricular infarct and microstructurally dispersed biomaterial delivered 1 week after infarct induction was developed from ex vivo microcomputed tomography data. The volumetric mesh density varied between 303 mm

Indexed as

Mechanotransduction, CellularMyocardial InfarctionAnimalsBiocompatible MaterialsHeart VentriclesMyocardiumMyocytes, CardiacRatsX-Ray MicrotomographyBiocompatible Materialsbiomaterial injection therapycardiac mechanicsfinite element methodmyocardial infarction

Identifiers

PMID36864599
PMCPMC10909490
OpenAlexW4323037096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.