ArticleCerebral cortex (New York, N.Y. : 1991)2023
Altered functional dynamics gradient in schizophrenia with cigarette smoking.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Association Between Chronic Tobacco Smoking and Brain Alterations in Schizophrenia: A Systematic Review of Magnetic Resonance Imaging Studies.Schizophrenia bulletin · 2025Pooled it
- A Method for Estimating Dynamic Functional Network Connectivity Gradients (dFNGs) From ICA Captures Smooth Inter-Network Modulation.Human brain mapping · 2025Article
- The structure of spontaneous speech changes in Alzheimer's disease: Crosslingual evidence from English and Greek.PloS one · 2025Article
- Extracting interpretable signatures of whole-brain dynamics through systematic comparison.PLoS computational biology · 2024Article
- A method for estimating dynamic functional network connectivity gradients (dFNG) from ICA captures smooth inter-network modulation.bioRxiv : the preprint server for biology · 2024Article
- Extracting interpretable signatures of whole-brain dynamics through systematic comparison.bioRxiv : the preprint server for biology · 2024Article
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Abstract
Schizophrenia is associated with a high prevalence of cigarette smoking. Neural dynamics are spatially structured and shaped by both microscale molecular and macroscale functional architectures, which are disturbed in the diseased brain. The neural mechanism underlying the schizophrenia-nicotine dependence comorbidity remains unknown. In this study, we aimed to test whether there is an interaction between schizophrenia and smoking in brain neural dynamics, and how the main effect of the 2 factors related to the molecular architecture. Functional magnetic resonance imaging data were obtained from 4 groups: schizophrenia and healthy controls with/without smoking. We identified 2 dynamics gradients combined with over 5,000 statistical features of the brain region's time series. The interaction effect was found in the high-order functional network, and the main effect of schizophrenia was in the bilateral orbitofrontal cortices. Moreover, the disease- and smoking-related alteration in brain pattern was associated with spatial distribution of serotonin, cannabinoid, and glutamate. Collectively, these findings supported the self-medication hypothesis in schizophrenia-nicotine dependence with a neural intrinsic dynamics perspective.
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